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Research Article

Expression Quantitative Trait Loci Are Highly Sensitive to Cellular Differentiation State

  • Alice Gerrits equal contributor,

    equal contributor Contributed equally to this work with: Alice Gerrits, Yang Li, Bruno M. Tesson

    Affiliation: Department of Cell Biology, Section Stem Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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  • Yang Li equal contributor,

    equal contributor Contributed equally to this work with: Alice Gerrits, Yang Li, Bruno M. Tesson

    Affiliation: Groningen Bioinformatics Centre, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Haren, The Netherlands

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  • Bruno M. Tesson equal contributor,

    equal contributor Contributed equally to this work with: Alice Gerrits, Yang Li, Bruno M. Tesson

    Affiliation: Groningen Bioinformatics Centre, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Haren, The Netherlands

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  • Leonid V. Bystrykh,

    Affiliation: Department of Cell Biology, Section Stem Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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  • Ellen Weersing,

    Affiliation: Department of Cell Biology, Section Stem Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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  • Albertina Ausema,

    Affiliation: Department of Cell Biology, Section Stem Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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  • Bert Dontje,

    Affiliation: Department of Cell Biology, Section Stem Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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  • Xusheng Wang,

    Affiliations: Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Institute of Bioinformatics, Zhejiang University, Hangzhou, China

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  • Rainer Breitling,

    Affiliation: Groningen Bioinformatics Centre, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Haren, The Netherlands

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  • Ritsert C. Jansen mail,

    r.c.jansen@rug.nl (RCJ); g.de.haan@med.umcg.nl (GdH)

    Affiliation: Groningen Bioinformatics Centre, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Haren, The Netherlands

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  • Gerald de Haan mail

    r.c.jansen@rug.nl (RCJ); g.de.haan@med.umcg.nl (GdH)

    Affiliation: Department of Cell Biology, Section Stem Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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  • Published: October 16, 2009
  • DOI: 10.1371/journal.pgen.1000692

About the Authors

Alice Gerrits, Leonid V. Bystrykh, Ellen Weersing, Albertina Ausema, Bert Dontje, Gerald de Haan
Department of Cell Biology, Section Stem Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Yang Li, Bruno M. Tesson, Rainer Breitling, Ritsert C. Jansen
Groningen Bioinformatics Centre, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Haren, The Netherlands
Xusheng Wang
Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
Xusheng Wang
Institute of Bioinformatics, Zhejiang University, Hangzhou, China

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LVB RCJ GdH. Performed the experiments: AG LVB EW AA BD. Analyzed the data: AG YL BMT RB. Contributed reagents/materials/analysis tools: YL BMT XW RB RCJ. Wrote the paper: AG YL BMT RB RCJ GdH.