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Research Article

Notch Is a Critical Component of the Mouse Somitogenesis Oscillator and Is Essential for the Formation of the Somites

  • Zoltan Ferjentsik,

    Affiliation: Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom

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  • Shinichi Hayashi equal contributor,

    equal contributor Contributed equally to this work with: Shinichi Hayashi, J. Kim Dale

    Affiliation: Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan

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  • J. Kim Dale equal contributor,

    equal contributor Contributed equally to this work with: Shinichi Hayashi, J. Kim Dale

    Affiliation: Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom

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  • Yasumasa Bessho,

    Affiliation: Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan

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  • An Herreman,

    Affiliations: Department of Molecular and Developmental Genetics, Vlaams Instituut voor Biotechnologie, Leuven, Belgium, Center for Human Genetics, KULeuven, Leuven, Belgium

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  • Bart De Strooper,

    Affiliations: Department of Molecular and Developmental Genetics, Vlaams Instituut voor Biotechnologie, Leuven, Belgium, Center for Human Genetics, KULeuven, Leuven, Belgium

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  • Gonzalo del Monte,

    Affiliation: Cardiovascular Developmental Biology Department, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain

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  • Jose Luis de la Pompa,

    Affiliation: Cardiovascular Developmental Biology Department, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain

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  • Miguel Maroto mail

    m.maroto@dundee.ac.uk

    Affiliation: Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom

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  • Published: September 25, 2009
  • DOI: 10.1371/journal.pgen.1000662

About the Authors

Zoltan Ferjentsik, J. Kim Dale, Miguel Maroto
Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom
Shinichi Hayashi, Yasumasa Bessho
Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan
An Herreman, Bart De Strooper
Department of Molecular and Developmental Genetics, Vlaams Instituut voor Biotechnologie, Leuven, Belgium
An Herreman, Bart De Strooper
Center for Human Genetics, KULeuven, Leuven, Belgium
Gonzalo del Monte, Jose Luis de la Pompa
Cardiovascular Developmental Biology Department, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain

Corresponding Author

Email: m.maroto@dundee.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JKD YB MM. Performed the experiments: ZF SH JKD AH GdM MM. Analyzed the data: ZF SH JKD YB AH BDS GdM JLdlP MM. Contributed reagents/materials/analysis tools: ZF SH JKD YB AH BDS GdM JLdlP MM. Wrote the paper: JKD MM.