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Research Article

RAD50 Is Required for Efficient Initiation of Resection and Recombinational Repair at Random, γ-Induced Double-Strand Break Ends

  • Jim Westmoreland,

    Affiliation: Chromosome Stability Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America

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  • Wenjian Ma,

    Affiliation: Chromosome Stability Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America

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  • Yan Yan,

    Affiliation: Chromosome Stability Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America

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  • Kelly Van Hulle,

    Affiliation: Biology Department, Indiana University–Purdue University, Indianapolis, Indiana, United States of America

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  • Anna Malkova,

    Affiliation: Biology Department, Indiana University–Purdue University, Indianapolis, Indiana, United States of America

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  • Michael A. Resnick mail

    resnick@niehs.nih.gov

    Affiliation: Chromosome Stability Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America

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  • Published: September 18, 2009
  • DOI: 10.1371/journal.pgen.1000656

About the Authors

Jim Westmoreland, Wenjian Ma, Yan Yan, Michael A. Resnick
Chromosome Stability Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
Kelly Van Hulle, Anna Malkova
Biology Department, Indiana University–Purdue University, Indianapolis, Indiana, United States of America

Corresponding Author

Email: resnick@niehs.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JW WM AM MAR. Performed the experiments: JW WM YY KVH AM. Analyzed the data: JW WM AM MAR. Wrote the paper: MAR.