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Research Article

A Systems Genetics Approach Implicates USF1, FADS3, and Other Causal Candidate Genes for Familial Combined Hyperlipidemia

  • Christopher L. Plaisier,

    Affiliation: Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America

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  • Steve Horvath,

    Affiliation: Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America

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  • Adriana Huertas-Vazquez,

    Affiliation: Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America

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  • Ivette Cruz-Bautista,

    Affiliation: Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

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  • Miguel F. Herrera,

    Affiliation: Surgery Division, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

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  • Teresa Tusie-Luna,

    Affiliation: Molecular Biology and Genomic Medicine Unit, Instituto de Investigaciones Biomédicas de la UNAM, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

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  • Carlos Aguilar-Salinas,

    Affiliation: Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

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  • Päivi Pajukanta mail

    ppajukanta@mednet.ucla.edu

    Affiliation: Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America

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  • Published: September 11, 2009
  • DOI: 10.1371/journal.pgen.1000642

About the Authors

Christopher L. Plaisier, Steve Horvath, Adriana Huertas-Vazquez, Päivi Pajukanta
Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
Ivette Cruz-Bautista, Carlos Aguilar-Salinas
Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Miguel F. Herrera
Surgery Division, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Teresa Tusie-Luna
Molecular Biology and Genomic Medicine Unit, Instituto de Investigaciones Biomédicas de la UNAM, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

Corresponding Author

Email: ppajukanta@mednet.ucla.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CLP TTL CAS PP. Performed the experiments: CLP AHV PP. Analyzed the data: CLP PP. Contributed reagents/materials/analysis tools: CLP SH AHV ICB MFH TTL CAS PP. Wrote the paper: CLP SH TTL CAS PP.