Advertisement
Research Article

The Variant rs1867277 in FOXE1 Gene Confers Thyroid Cancer Susceptibility through the Recruitment of USF1/USF2 Transcription Factors

  • Iñigo Landa equal contributor,

    equal contributor Contributed equally to this work with: Iñigo Landa, Sergio Ruiz-Llorente

    Affiliation: Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain

    X
  • Sergio Ruiz-Llorente equal contributor,

    equal contributor Contributed equally to this work with: Iñigo Landa, Sergio Ruiz-Llorente

    Affiliation: Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas (CSIC), Autonomous University of Madrid (CSIC-UAM), Madrid, Spain

    X
  • Cristina Montero-Conde,

    Affiliations: Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain, Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas (CSIC), Autonomous University of Madrid (CSIC-UAM), Madrid, Spain

    X
  • Lucía Inglada-Pérez,

    Affiliations: Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain, ISCIII Centre for Biomedical Research on Rare Diseases (CIBERER), Madrid, Spain

    X
  • Francesca Schiavi,

    Affiliation: Familial Cancer Clinic, Veneto Institute of Oncology IRCCS, Padova, Italy

    X
  • Susanna Leskelä,

    Affiliation: Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain

    X
  • Guillermo Pita,

    Affiliation: Genotyping Unit-CEGEN, Spanish National Cancer Research Centre (CNIO), Madrid, Spain

    X
  • Roger Milne,

    Affiliation: Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain

    X
  • Javier Maravall,

    Affiliation: Hospital Universitario Arnau de Vilanova-IRB Lleida, Lleida, Spain

    X
  • Ignacio Ramos,

    Affiliation: Hospital de Requena, Valencia, Spain

    X
  • Víctor Andía,

    Affiliation: Hospital General Universitario Gregorio Marañón, Madrid, Spain

    X
  • Paloma Rodríguez-Poyo,

    Affiliation: Hospital General Universitario Gregorio Marañón, Madrid, Spain

    X
  • Antonino Jara-Albarrán,

    Affiliation: Hospital General Universitario Gregorio Marañón, Madrid, Spain

    X
  • Amparo Meoro,

    Affiliation: Hospital Universitario Reina Sofía, Murcia, Spain

    X
  • Cristina del Peso,

    Affiliation: Hospital Universitario Reina Sofía, Murcia, Spain

    X
  • Luis Arribas,

    Affiliation: Hospital Marina Alta, Denia, Spain

    X
  • Pedro Iglesias,

    Affiliation: Hospital General de Segovia, Segovia, Spain

    X
  • Javier Caballero,

    Affiliation: Hospital Reina Sofía, Córdoba, Spain

    X
  • Joaquín Serrano,

    Affiliation: Hospital General Universitario de Alicante, Alicante, Spain

    X
  • Antonio Picó,

    Affiliation: Hospital General Universitario de Alicante, Alicante, Spain

    X
  • Francisco Pomares,

    Affiliation: Hospital Universitario San Juan de Alicante, Alicante, Spain

    X
  • Gabriel Giménez,

    Affiliation: Hospital de Sabadell-Parc Taulí, Sabadell, Spain

    X
  • Pedro López-Mondéjar,

    Affiliation: Hospital General Universitario de Elche, Elche, Spain

    X
  • Roberto Castello,

    Affiliation: Civil Hospital, Verona, Italy

    X
  • Isabella Merante-Boschin,

    Affiliation: Surgical Pathology, Department of Medical and Surgical Sciences, University of Padova, Padova, Italy

    X
  • Maria-Rosa Pelizzo,

    Affiliation: Surgical Pathology, Department of Medical and Surgical Sciences, University of Padova, Padova, Italy

    X
  • Didac Mauricio,

    Affiliation: Hospital Universitario Arnau de Vilanova-IRB Lleida, Lleida, Spain

    X
  • Giuseppe Opocher,

    Affiliations: Familial Cancer Clinic, Veneto Institute of Oncology IRCCS, Padova, Italy, Department of Medical and Surgical Sciences, University of Padova, Padova, Italy

    X
  • Cristina Rodríguez-Antona,

    Affiliations: Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain, ISCIII Centre for Biomedical Research on Rare Diseases (CIBERER), Madrid, Spain

    X
  • Anna González-Neira,

    Affiliation: Genotyping Unit-CEGEN, Spanish National Cancer Research Centre (CNIO), Madrid, Spain

    X
  • Xavier Matías-Guiu,

    Affiliation: Hospital Universitario Arnau de Vilanova-IRB Lleida, Lleida, Spain

    X
  • Pilar Santisteban mail,

    psantisteban@iib.uam.es (PS); mrobledo@cnio.es (MR)

    Affiliation: Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas (CSIC), Autonomous University of Madrid (CSIC-UAM), Madrid, Spain

    X
  • Mercedes Robledo mail

    psantisteban@iib.uam.es (PS); mrobledo@cnio.es (MR)

    Affiliations: Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain, ISCIII Centre for Biomedical Research on Rare Diseases (CIBERER), Madrid, Spain

    X
  • Published: September 04, 2009
  • DOI: 10.1371/journal.pgen.1000637

About the Authors

Iñigo Landa, Cristina Montero-Conde, Lucía Inglada-Pérez, Susanna Leskelä, Cristina Rodríguez-Antona, Mercedes Robledo
Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain
Sergio Ruiz-Llorente, Cristina Montero-Conde, Pilar Santisteban
Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas (CSIC), Autonomous University of Madrid (CSIC-UAM), Madrid, Spain
Lucía Inglada-Pérez, Cristina Rodríguez-Antona, Mercedes Robledo
ISCIII Centre for Biomedical Research on Rare Diseases (CIBERER), Madrid, Spain
Francesca Schiavi, Giuseppe Opocher
Familial Cancer Clinic, Veneto Institute of Oncology IRCCS, Padova, Italy
Guillermo Pita, Anna González-Neira
Genotyping Unit-CEGEN, Spanish National Cancer Research Centre (CNIO), Madrid, Spain
Roger Milne
Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain
Javier Maravall, Didac Mauricio, Xavier Matías-Guiu
Hospital Universitario Arnau de Vilanova-IRB Lleida, Lleida, Spain
Ignacio Ramos
Hospital de Requena, Valencia, Spain
Víctor Andía, Paloma Rodríguez-Poyo, Antonino Jara-Albarrán
Hospital General Universitario Gregorio Marañón, Madrid, Spain
Amparo Meoro, Cristina del Peso
Hospital Universitario Reina Sofía, Murcia, Spain
Luis Arribas
Hospital Marina Alta, Denia, Spain
Pedro Iglesias
Hospital General de Segovia, Segovia, Spain
Javier Caballero
Hospital Reina Sofía, Córdoba, Spain
Joaquín Serrano, Antonio Picó
Hospital General Universitario de Alicante, Alicante, Spain
Francisco Pomares
Hospital Universitario San Juan de Alicante, Alicante, Spain
Gabriel Giménez
Hospital de Sabadell-Parc Taulí, Sabadell, Spain
Pedro López-Mondéjar
Hospital General Universitario de Elche, Elche, Spain
Roberto Castello
Civil Hospital, Verona, Italy
Isabella Merante-Boschin, Maria-Rosa Pelizzo
Surgical Pathology, Department of Medical and Surgical Sciences, University of Padova, Padova, Italy
Giuseppe Opocher
Department of Medical and Surgical Sciences, University of Padova, Padova, Italy

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PS MR. Performed the experiments: IL SRL CMC SL. Analyzed the data: IL SRL LIP GP RM AGN. Contributed reagents/materials/analysis tools: FS JM IR VA PRP AJA AM CdP LA PI JC JS AP FP GG PLM RC IMB MRP DM GO XMG. Wrote the paper: IL SRL CRA PS MR.