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Research Article

The Fission Yeast Homeodomain Protein Yox1p Binds to MBF and Confines MBF-Dependent Cell-Cycle Transcription to G1-S via Negative Feedback

  • Sofia Aligianni,

    Affiliation: Department of Genetics, Evolution & Environment and UCL Cancer Institute, University College London, London, United Kingdom

    Current address: Department of Biology, University of California San Diego, La Jolla, California, United States of America

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  • Daniel H. Lackner,

    Affiliation: Department of Genetics, Evolution & Environment and UCL Cancer Institute, University College London, London, United Kingdom

    Current address: Salk Institute for Biological Studies, La Jolla, California, United States of America

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  • Steffi Klier,

    Affiliation: MRC Laboratory for Molecular Cell Biology, University College London, London, United Kingdom

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  • Gabriella Rustici,

    Affiliation: EMBL Outstation–Hinxton, European Bioinformatics Institute, Cambridge, United Kingdom

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  • Brian T. Wilhelm,

    Affiliation: Department of Genetics, Evolution & Environment and UCL Cancer Institute, University College London, London, United Kingdom

    Current address: Institute for Research in Immunology and Cancer (IRIC), Montréal, Québec, Canada

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  • Samuel Marguerat,

    Affiliation: Department of Genetics, Evolution & Environment and UCL Cancer Institute, University College London, London, United Kingdom

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  • Sandra Codlin,

    Affiliation: Department of Genetics, Evolution & Environment and UCL Cancer Institute, University College London, London, United Kingdom

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  • Alvis Brazma,

    Affiliation: EMBL Outstation–Hinxton, European Bioinformatics Institute, Cambridge, United Kingdom

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  • Robertus A. M. de Bruin,

    Affiliation: MRC Laboratory for Molecular Cell Biology, University College London, London, United Kingdom

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  • Jürg Bähler mail

    j.bahler@ucl.ac.uk

    Affiliation: Department of Genetics, Evolution & Environment and UCL Cancer Institute, University College London, London, United Kingdom

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  • Published: August 28, 2009
  • DOI: 10.1371/journal.pgen.1000626

About the Authors

Sofia Aligianni, Daniel H. Lackner, Brian T. Wilhelm, Samuel Marguerat, Sandra Codlin, Jürg Bähler
Department of Genetics, Evolution & Environment and UCL Cancer Institute, University College London, London, United Kingdom
Steffi Klier, Robertus A. M. de Bruin
MRC Laboratory for Molecular Cell Biology, University College London, London, United Kingdom
Gabriella Rustici, Alvis Brazma
EMBL Outstation–Hinxton, European Bioinformatics Institute, Cambridge, United Kingdom

Corresponding Author

Email: j.bahler@ucl.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SA RAMdB JB. Performed the experiments: SA DHL SK GR BTW SC. Analyzed the data: SA DHL GR BTW SM RAMdB JB. Contributed reagents/materials/analysis tools: SM AB. Wrote the paper: JB.