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Research Article

A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene

  • Chris Church,

    Affiliation: MRC Harwell, Metabolism and Inflammation, Harwell Science and Innovation Campus, Harwell, United Kingdom

    X
  • Sheena Lee equal contributor,

    equal contributor Contributed equally to this work with: Sheena Lee, Eleanor A. L. Bagg, James S. McTaggart

    Affiliation: Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom

    X
  • Eleanor A. L. Bagg equal contributor,

    equal contributor Contributed equally to this work with: Sheena Lee, Eleanor A. L. Bagg, James S. McTaggart

    Affiliation: Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, Oxford, United Kingdom

    X
  • James S. McTaggart equal contributor,

    equal contributor Contributed equally to this work with: Sheena Lee, Eleanor A. L. Bagg, James S. McTaggart

    Affiliation: Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom

    X
  • Robert Deacon,

    Affiliation: Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom

    X
  • Thomas Gerken,

    Affiliation: Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, Oxford, United Kingdom

    X
  • Angela Lee,

    Affiliation: MRC Harwell, Metabolism and Inflammation, Harwell Science and Innovation Campus, Harwell, United Kingdom

    X
  • Lee Moir,

    Affiliation: MRC Harwell, Metabolism and Inflammation, Harwell Science and Innovation Campus, Harwell, United Kingdom

    X
  • Jasmin Mecinović,

    Affiliation: Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, Oxford, United Kingdom

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  • Mohamed M. Quwailid,

    Affiliation: MRC Harwell, Metabolism and Inflammation, Harwell Science and Innovation Campus, Harwell, United Kingdom

    X
  • Christopher J. Schofield ,

    Affiliation: Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, Oxford, United Kingdom

    These authors also contributed equally to this work.

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  • Frances M. Ashcroft ,

    Affiliation: Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom

    These authors also contributed equally to this work.

    X
  • Roger D. Cox mail

    r.cox@har.mrc.ac.uk

    Affiliation: MRC Harwell, Metabolism and Inflammation, Harwell Science and Innovation Campus, Harwell, United Kingdom

    X
  • Published: August 14, 2009
  • DOI: 10.1371/journal.pgen.1000599

About the Authors

Chris Church, Angela Lee, Lee Moir, Mohamed M. Quwailid, Roger D. Cox
MRC Harwell, Metabolism and Inflammation, Harwell Science and Innovation Campus, Harwell, United Kingdom
Sheena Lee, James S. McTaggart, Frances M. Ashcroft
Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom
Eleanor A. L. Bagg, Thomas Gerken, Jasmin Mecinović, Christopher J. Schofield
Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, Oxford, United Kingdom
Robert Deacon
Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom

Corresponding Author

Email: r.cox@har.mrc.ac.uk

Competing Interests

CJS is a co-founder of ReOx, a company that aims to exploit discoveries on the hypoxic response for therapeutic benefit.

Author Contributions

Conceived and designed the experiments: CC CJS FMA RDC. Performed the experiments: CC SL EALB JSM RD TG AL LM JM MMQ. Analyzed the data: CC SL EALB JSM RD TG AL JM MMQ CJS FMA RDC. Wrote the paper: CC EALB CJS FMA RDC.