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Research Article

Evolutionary Processes Acting on Candidate cis-Regulatory Regions in Humans Inferred from Patterns of Polymorphism and Divergence

  • Dara G. Torgerson mail,

    dara@uchicago.edu

    Affiliation: Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America

    Current address: Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

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  • Adam R. Boyko,

    Affiliation: Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America

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  • Ryan D. Hernandez,

    Affiliation: Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America

    Current address: Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

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  • Amit Indap,

    Affiliation: Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America

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  • Xiaolan Hu,

    Affiliation: Celera Diagnostics, Alameda, California, United States of America

    Current address: Pharmacogenomics, Pfizer Global Research and Development, Groton, Connecticut, United States of America

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  • Thomas J. White,

    Affiliation: Celera Diagnostics, Alameda, California, United States of America

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  • John J. Sninsky,

    Affiliation: Celera Diagnostics, Alameda, California, United States of America

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  • Michele Cargill,

    Affiliation: Celera Diagnostics, Alameda, California, United States of America

    Current address: Navigenics, Redwood Shores, California, United States of America

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  • Mark D. Adams,

    Affiliation: Celera Diagnostics, Alameda, California, United States of America

    Current address: Department of Genetics, Case Western Reserve University, Cleveland, Ohio, United States of America

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  • Carlos D. Bustamante,

    Affiliation: Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America

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  • Andrew G. Clark

    Affiliation: Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America

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  • Published: August 07, 2009
  • DOI: 10.1371/journal.pgen.1000592

About the Authors

Dara G. Torgerson, Andrew G. Clark
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America
Adam R. Boyko, Ryan D. Hernandez, Amit Indap, Carlos D. Bustamante
Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America
Xiaolan Hu, Thomas J. White, John J. Sninsky, Michele Cargill, Mark D. Adams
Celera Diagnostics, Alameda, California, United States of America

Corresponding Author

Email: dara@uchicago.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DGT ARB RDH TJW JJS MC MDA CDB AGC. Performed the experiments: DGT ARB RDH AI XH. Analyzed the data: DGT ARB RDH AI XH. Contributed reagents/materials/analysis tools: DGT ARB RDH AI XH CDB. Wrote the paper: DGT ARB RDH CDB AGC.