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Research Article

A Computational Screen for Regulators of Oxidative Phosphorylation Implicates SLIRP in Mitochondrial RNA Homeostasis

  • Joshua M. Baughman,

    Affiliations: Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Roland Nilsson,

    Affiliations: Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Vishal M. Gohil,

    Affiliations: Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Daniel H. Arlow,

    Affiliations: Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Zareen Gauhar,

    Affiliations: Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Vamsi K. Mootha mail

    vamsi@hms.harvard.edu

    Affiliations: Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Published: August 14, 2009
  • DOI: 10.1371/journal.pgen.1000590

About the Authors

Joshua M. Baughman, Roland Nilsson, Vishal M. Gohil, Daniel H. Arlow, Zareen Gauhar, Vamsi K. Mootha
Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Joshua M. Baughman, Roland Nilsson, Vishal M. Gohil, Daniel H. Arlow, Zareen Gauhar, Vamsi K. Mootha
Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
Joshua M. Baughman, Roland Nilsson, Vishal M. Gohil, Daniel H. Arlow, Zareen Gauhar, Vamsi K. Mootha
Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Corresponding Author

Email: vamsi@hms.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JMB RN VKM. Performed the experiments: JMB RN ZG. Analyzed the data: JMB RN. Contributed reagents/materials/analysis tools: JMB RN VMG DHA. Wrote the paper: JMB RN VKM.