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Research Article

On Quality Control Measures in Genome-Wide Association Studies: A Test to Assess the Genotyping Quality of Individual Probands in Family-Based Association Studies and an Application to the HapMap Data

  • David W. Fardo,

    Affiliation: Department of Biostatistics, University of Kentucky College of Public Health, Lexington, Kentucky, United States of America

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  • Iuliana Ionita-Laza,

    Affiliation: Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Christoph Lange mail

    clange@hsph.harvard.edu

    Affiliations: Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America, Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: July 24, 2009
  • DOI: 10.1371/journal.pgen.1000572

About the Authors

David W. Fardo
Department of Biostatistics, University of Kentucky College of Public Health, Lexington, Kentucky, United States of America
Iuliana Ionita-Laza, Christoph Lange
Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America
Christoph Lange
Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Corresponding Author

Email: clange@hsph.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DWF CL. Performed the experiments: DWF IIL CL. Analyzed the data: DWF IIL CL. Contributed reagents/materials/analysis tools: DWF IIL CL. Wrote the paper: DWF CL.