Advertisement
Research Article

A Targeted Constitutive Mutation in the Apc Tumor Suppressor Gene Underlies Mammary But Not Intestinal Tumorigenesis

  • Claudia Gaspar,

    Affiliation: Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands

    X
  • Patrick Franken,

    Affiliation: Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands

    X
  • Lia Molenaar,

    Affiliation: Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands

    X
  • Cor Breukel,

    Affiliation: Human and Clinical Genetics Center, LUMC, Leiden, The Netherlands

    X
  • Martin van der Valk,

    Affiliation: Department of Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands

    X
  • Ron Smits,

    Affiliation: Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands

    X
  • Riccardo Fodde mail

    r.fodde@erasmusmc.nl

    Affiliation: Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands

    X
  • Published: July 03, 2009
  • DOI: 10.1371/journal.pgen.1000547

About the Authors

Claudia Gaspar, Patrick Franken, Lia Molenaar, Ron Smits, Riccardo Fodde
Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
Cor Breukel
Human and Clinical Genetics Center, LUMC, Leiden, The Netherlands
Martin van der Valk
Department of Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands

Corresponding Author

Email: r.fodde@erasmusmc.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RF. Performed the experiments: CG PF LM CB MvdV. Analyzed the data: CG MvdV RS RF. Contributed reagents/materials/analysis tools: RS. Wrote the paper: RF.