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Research Article

Comprehensive Linkage and Association Analyses Identify Haplotype, Near to the TNFSF15 Gene, Significantly Associated with Spondyloarthritis

  • Elena Zinovieva,

    Affiliations: Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France, INSERM U567, Paris, France

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  • Catherine Bourgain,

    Affiliation: INSERM U535, Université Paris Sud – Paul Brousse Hospital, Villejuif, France

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  • Amir Kadi,

    Affiliations: Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France, INSERM U567, Paris, France

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  • Franck Letourneur,

    Affiliations: Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France, INSERM U567, Paris, France

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  • Brigitte Izac,

    Affiliations: Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France, INSERM U567, Paris, France

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  • Roula Said-Nahal,

    Affiliation: Rheumatology Division, Ambroise Paré Hospital (AP-HP), and Versailles Saint Quentin en Yvelines University, Boulogne-Billancourt, France

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  • Nicolas Lebrun,

    Affiliations: Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France, INSERM U567, Paris, France

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  • Nicolas Cagnard,

    Affiliation: Bioinformatics Platform, Faculty of Medicine Paris Descartes, Necker Hospital, Paris, France

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  • Agathe Vigier,

    Affiliations: Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France, INSERM U567, Paris, France

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  • Sébastien Jacques,

    Affiliations: Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France, INSERM U567, Paris, France

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  • Corinne Miceli-Richard,

    Affiliation: Rheumatology Division, Kremlin-Bicêtre Hospital (AP-HP), Kremlin-Bicêtre, France

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  • Henri-Jean Garchon,

    Affiliations: Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France, INSERM U567, Paris, France

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  • Simon Heath,

    Affiliation: National Genotyping Center (CNG), Evry, France

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  • Céline Charon,

    Affiliation: National Genotyping Center (CNG), Evry, France

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  • Delphine Bacq,

    Affiliation: National Genotyping Center (CNG), Evry, France

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  • Anne Boland,

    Affiliation: National Genotyping Center (CNG), Evry, France

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  • Diana Zelenika,

    Affiliation: National Genotyping Center (CNG), Evry, France

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  • Gilles Chiocchia equal contributor,

    equal contributor Contributed equally to this work with: Gilles Chiocchia, Maxime Breban

    Affiliations: Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France, INSERM U567, Paris, France, Rheumatology Division, Ambroise Paré Hospital (AP-HP), and Versailles Saint Quentin en Yvelines University, Boulogne-Billancourt, France

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  • Maxime Breban equal contributor mail

    equal contributor Contributed equally to this work with: Gilles Chiocchia, Maxime Breban

    maxime.breban@apr.aphp.fr

    Affiliations: Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France, INSERM U567, Paris, France, Rheumatology Division, Ambroise Paré Hospital (AP-HP), and Versailles Saint Quentin en Yvelines University, Boulogne-Billancourt, France

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  • Published: June 19, 2009
  • DOI: 10.1371/journal.pgen.1000528

About the Authors

Elena Zinovieva, Amir Kadi, Franck Letourneur, Brigitte Izac, Nicolas Lebrun, Agathe Vigier, Sébastien Jacques, Henri-Jean Garchon, Gilles Chiocchia, Maxime Breban
Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France
Elena Zinovieva, Amir Kadi, Franck Letourneur, Brigitte Izac, Nicolas Lebrun, Agathe Vigier, Sébastien Jacques, Henri-Jean Garchon, Gilles Chiocchia, Maxime Breban
INSERM U567, Paris, France
Catherine Bourgain
INSERM U535, Université Paris Sud – Paul Brousse Hospital, Villejuif, France
Roula Said-Nahal, Gilles Chiocchia, Maxime Breban
Rheumatology Division, Ambroise Paré Hospital (AP-HP), and Versailles Saint Quentin en Yvelines University, Boulogne-Billancourt, France
Nicolas Cagnard
Bioinformatics Platform, Faculty of Medicine Paris Descartes, Necker Hospital, Paris, France
Corinne Miceli-Richard
Rheumatology Division, Kremlin-Bicêtre Hospital (AP-HP), Kremlin-Bicêtre, France
Simon Heath, Céline Charon, Delphine Bacq, Anne Boland, Diana Zelenika
National Genotyping Center (CNG), Evry, France

Corresponding Author

Email: maxime.breban@apr.aphp.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EZ CB AK FL BI RSN CMR HJG SH DZ GC MB. Performed the experiments: EZ AK FL BI NL AV SJ SH CC DB AB. Analyzed the data: EZ CB AK FL BI NL NC AV HJG SH CC AB DZ GC MB. Contributed reagents/materials/analysis tools: CB FL RSN NL NC MB. Wrote the paper: EZ CB CC GC MB.