Advertisement
Research Article

Sensitive Detection of Chromosomal Segments of Distinct Ancestry in Admixed Populations

  • Alkes L. Price,

    Affiliations: Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America, Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

    X
  • Arti Tandon,

    Affiliations: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Nick Patterson,

    Affiliation: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

    X
  • Kathleen C. Barnes,

    Affiliation: Johns Hopkins Allergy and Asthma Center, Division of Clinical Immunology, Department of Medicine, School of Medicine, Baltimore, Maryland, United States of America

    X
  • Nicholas Rafaels,

    Affiliation: Johns Hopkins Allergy and Asthma Center, Division of Clinical Immunology, Department of Medicine, School of Medicine, Baltimore, Maryland, United States of America

    X
  • Ingo Ruczinski,

    Affiliation: Department of Biostatistics, Johns Hopkins School of Public Health, Baltimore, Maryland, United States of America

    X
  • Terri H. Beaty,

    Affiliation: Department of Biostatistics, Johns Hopkins School of Public Health, Baltimore, Maryland, United States of America

    X
  • Rasika Mathias,

    Affiliation: Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland, United States of America

    X
  • David Reich mail,

    reich@genetics.med.harvard.edu (DR); myers@stats.ox.ac.uk (SM)

    Affiliations: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Simon Myers mail

    reich@genetics.med.harvard.edu (DR); myers@stats.ox.ac.uk (SM)

    Affiliations: Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Department of Statistics, Oxford University, Oxford, United Kingdom, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

    X
  • Published: June 19, 2009
  • DOI: 10.1371/journal.pgen.1000519

About the Authors

Alkes L. Price
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
Alkes L. Price
Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America
Alkes L. Price, Arti Tandon, Nick Patterson, David Reich, Simon Myers
Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
Arti Tandon, David Reich
Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
Kathleen C. Barnes, Nicholas Rafaels
Johns Hopkins Allergy and Asthma Center, Division of Clinical Immunology, Department of Medicine, School of Medicine, Baltimore, Maryland, United States of America
Ingo Ruczinski, Terri H. Beaty
Department of Biostatistics, Johns Hopkins School of Public Health, Baltimore, Maryland, United States of America
Rasika Mathias
Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland, United States of America
Simon Myers
Department of Statistics, Oxford University, Oxford, United Kingdom
Simon Myers
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ALP NP DR SM. Performed the experiments: ALP AT NP KCB NR IR THB RM DR SM. Analyzed the data: ALP AT NP DR SM. Contributed reagents/materials/analysis tools: ALP NP KCB NR IR THB RM DR SM. Wrote the paper: ALP AT NP KCB NR IR THB RM DR SM.