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Research Article

The Level of the Transcription Factor Pax6 Is Essential for Controlling the Balance between Neural Stem Cell Self-Renewal and Neurogenesis

  • Stephen N. Sansom,

    Affiliation: Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom

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  • Dean S. Griffiths equal contributor,

    equal contributor Contributed equally to this work with: Dean S. Griffiths, Andrea Faedo

    Affiliation: Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom

    Current address: Cambridge Institute for Medical Research, Cambridge, United Kingdom

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  • Andrea Faedo equal contributor,

    equal contributor Contributed equally to this work with: Dean S. Griffiths, Andrea Faedo

    Affiliation: Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California at San Francisco, San Francisco, California, United States of America

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  • Dirk-Jan Kleinjan,

    Affiliation: Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom

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  • Youlin Ruan,

    Affiliation: Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California at San Francisco, San Francisco, California, United States of America

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  • James Smith,

    Affiliation: Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom

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  • Veronica van Heyningen,

    Affiliation: Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom

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  • John L. Rubenstein,

    Affiliation: Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California at San Francisco, San Francisco, California, United States of America

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  • Frederick J. Livesey mail

    rick@gurdon.cam.ac.uk

    Affiliation: Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom

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  • Published: June 12, 2009
  • DOI: 10.1371/journal.pgen.1000511

About the Authors

Stephen N. Sansom, Dean S. Griffiths, James Smith, Frederick J. Livesey
Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom
Andrea Faedo, Youlin Ruan, John L. Rubenstein
Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California at San Francisco, San Francisco, California, United States of America
Dirk-Jan Kleinjan, Veronica van Heyningen
Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom

Corresponding Author

Email: rick@gurdon.cam.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SNS FJL. Performed the experiments: SNS DSG AF JS. Analyzed the data: SNS DSG AF JLR FJL. Contributed reagents/materials/analysis tools: DJK YR VvH JLR. Wrote the paper: SNS FJL.