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Research Article

Admixture Mapping of 15,280 African Americans Identifies Obesity Susceptibility Loci on Chromosomes 5 and X

  • Ching-Yu Cheng mail,

    cycheng@jhsph.edu (CYC); wkao@jhsph.edu (WHLK); reich@genetics.med.harvard.edu (DR)

    Affiliations: Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, United States of America, Department of Ophthalmology, National Yang Ming University School of Medicine, Taipei, Taiwan, Taipei Veterans General Hospital, Taipei, Taiwan

    X
  • W. H. Linda Kao mail,

    cycheng@jhsph.edu (CYC); wkao@jhsph.edu (WHLK); reich@genetics.med.harvard.edu (DR)

    Affiliations: Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, United States of America, Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Maryland, United States of America

    X
  • Nick Patterson,

    Affiliation: Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

    X
  • Arti Tandon,

    Affiliations: Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Christopher A. Haiman,

    Affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

    X
  • Tamara B. Harris,

    Affiliation: Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland, United States of America

    X
  • Chao Xing,

    Affiliations: Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Donald W. Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

    X
  • Esther M. John,

    Affiliations: Northern California Cancer Center, Fremont, California, United States of America, Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California, United States of America, Stanford Cancer Center, Stanford, California, United States of America

    X
  • Christine B. Ambrosone,

    Affiliation: Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, United States of America

    X
  • Frederick L. Brancati,

    Affiliations: Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, United States of America, Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Maryland, United States of America

    X
  • Josef Coresh,

    Affiliations: Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, United States of America, Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Maryland, United States of America

    X
  • Michael F. Press,

    Affiliation: Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

    X
  • Rulan S. Parekh,

    Affiliations: Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland, United States of America, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America

    X
  • Michael J. Klag,

    Affiliations: Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, United States of America, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America, Department of Health Policy and Management, Johns Hopkins University, Baltimore, Maryland, United States of America

    X
  • Lucy A. Meoni,

    Affiliations: Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America, Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland, United States of America

    X
  • Wen-Chi Hsueh,

    Affiliation: Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

    X
  • Laura Fejerman,

    Affiliations: Department of Medicine, University of California San Francisco, San Francisco, California, United States of America, Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States of America

    X
  • Ludmila Pawlikowska,

    Affiliations: Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America, Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, United States of America

    X
  • Matthew L. Freedman,

    Affiliations: Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Department of Medical Oncology, Dana–Farber Cancer Institute, Boston, Massachusetts, United States of America

    X
  • Lina H. Jandorf,

    Affiliation: Department of Oncological Sciences, Mount Sinai School of Medicine, New York, New York, United States of America

    X
  • Elisa V. Bandera,

    Affiliation: The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, New Jersey, United States of America

    X
  • Gregory L. Ciupak,

    Affiliation: Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, United States of America

    X
  • Michael A. Nalls,

    Affiliations: Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland, United States of America, Molecular Genetics Section, Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America

    X
  • Ermeg L. Akylbekova,

    Affiliation: Jackson Heart Study Analysis Group, Jackson State University, Jackson, Mississippi, United States of America

    X
  • Eric S. Orwoll,

    Affiliation: Oregon Clinical and Translational Research Institute, Oregon Health and Science University, Portland, Oregon, United States of America

    X
  • Tennille S. Leak,

    Affiliation: Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

    X
  • Iva Miljkovic,

    Affiliation: Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

    X
  • Rongling Li,

    Affiliation: Department of Preventive Medicine, Division of Biostatistics and Epidemiology, University of Tennessee, Memphis, Tennessee, United States of America

    X
  • Giske Ursin,

    Affiliations: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America, Department of Nutrition, University of Oslo, Oslo, Norway

    X
  • Leslie Bernstein,

    Affiliations: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America, Department of Cancer Etiology, Division of Population Science, City of Hope National Medical Center, Duarte, California, United States of America

    X
  • Kristin Ardlie,

    Affiliations: Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Genomics Collaborative, Cambridge, Massachusetts, United States of America

    X
  • Herman A. Taylor,

    Affiliations: Jackson State University, Jackson, Mississippi, United States of America, Tougaloo College, Tougaloo, Mississippi, United States of America, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

    X
  • Eric Boerwinckle,

    Affiliation: Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, United States of America

    X
  • Joseph M. Zmuda,

    Affiliation: Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

    X
  • Brian E. Henderson,

    Affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

    X
  • James G. Wilson,

    Affiliations: University of Mississippi Medical Center, Jackson, Mississippi, United States of America, G. V. (Sonny) Montgomery Veterans Affairs Medical Center, Jackson, Mississippi, United States of America

    X
  • David Reich mail

    cycheng@jhsph.edu (CYC); wkao@jhsph.edu (WHLK); reich@genetics.med.harvard.edu (DR)

    Affiliations: Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Published: May 22, 2009
  • DOI: 10.1371/journal.pgen.1000490

About the Authors

Ching-Yu Cheng, W. H. Linda Kao, Frederick L. Brancati, Josef Coresh, Michael J. Klag
Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, United States of America
Ching-Yu Cheng
Department of Ophthalmology, National Yang Ming University School of Medicine, Taipei, Taiwan
Ching-Yu Cheng
Taipei Veterans General Hospital, Taipei, Taiwan
W. H. Linda Kao, Frederick L. Brancati, Josef Coresh
Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Maryland, United States of America
Nick Patterson, Arti Tandon, Matthew L. Freedman, Kristin Ardlie, David Reich
Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
Arti Tandon, David Reich
Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
Christopher A. Haiman, Giske Ursin, Leslie Bernstein, Brian E. Henderson
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
Tamara B. Harris, Michael A. Nalls
Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland, United States of America
Chao Xing
Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
Chao Xing
McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
Chao Xing
Donald W. Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
Esther M. John
Northern California Cancer Center, Fremont, California, United States of America
Esther M. John
Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California, United States of America
Esther M. John
Stanford Cancer Center, Stanford, California, United States of America
Christine B. Ambrosone, Gregory L. Ciupak
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, United States of America
Michael F. Press
Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
Rulan S. Parekh
Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland, United States of America
Rulan S. Parekh, Michael J. Klag, Lucy A. Meoni
Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America
Michael J. Klag
Department of Health Policy and Management, Johns Hopkins University, Baltimore, Maryland, United States of America
Lucy A. Meoni
Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland, United States of America
Wen-Chi Hsueh, Laura Fejerman
Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
Laura Fejerman, Ludmila Pawlikowska
Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America
Laura Fejerman
Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States of America
Ludmila Pawlikowska
Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, United States of America
Matthew L. Freedman
Department of Medical Oncology, Dana–Farber Cancer Institute, Boston, Massachusetts, United States of America
Lina H. Jandorf
Department of Oncological Sciences, Mount Sinai School of Medicine, New York, New York, United States of America
Elisa V. Bandera
The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, New Jersey, United States of America
Michael A. Nalls
Molecular Genetics Section, Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America
Ermeg L. Akylbekova
Jackson Heart Study Analysis Group, Jackson State University, Jackson, Mississippi, United States of America
Eric S. Orwoll
Oregon Clinical and Translational Research Institute, Oregon Health and Science University, Portland, Oregon, United States of America
Tennille S. Leak, Iva Miljkovic, Joseph M. Zmuda
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
Rongling Li
Department of Preventive Medicine, Division of Biostatistics and Epidemiology, University of Tennessee, Memphis, Tennessee, United States of America
Giske Ursin
Department of Nutrition, University of Oslo, Oslo, Norway
Leslie Bernstein
Department of Cancer Etiology, Division of Population Science, City of Hope National Medical Center, Duarte, California, United States of America
Kristin Ardlie
Genomics Collaborative, Cambridge, Massachusetts, United States of America
Herman A. Taylor
Jackson State University, Jackson, Mississippi, United States of America
Herman A. Taylor
Tougaloo College, Tougaloo, Mississippi, United States of America
Herman A. Taylor, James G. Wilson
University of Mississippi Medical Center, Jackson, Mississippi, United States of America
Eric Boerwinckle
Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
James G. Wilson
G. V. (Sonny) Montgomery Veterans Affairs Medical Center, Jackson, Mississippi, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CYC WHLK CAH TBH CX EMJ CBA GU LB KA JMZ BEH JGW DR. Performed the experiments: WHLK AT CAH TBH CX LF EB JMZ BEH JGW DR. Analyzed the data: CYC WHLK NP AT DR. Contributed reagents/materials/analysis tools: WHLK NP AT CAH TBH CX EMJ CBA FLB JC MFP RSP MJK LAM WCH LF LP MLF LHJ EVB GLC MAN ELA ESO TSL IM RL GU LB KA HAT EB JMZ BEH JGW DR. Wrote the paper: CYC WHLK NP DR.