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Research Article

Ancient mtDNA Genetic Variants Modulate mtDNA Transcription and Replication

  • Sarit Suissa,

    Affiliation: Department of Life Sciences and National Institute of Biotechnology (NIBN), Ben-Gurion University of the Negev, Beer-Sheva, Israel

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  • Zhibo Wang,

    Affiliation: Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Jason Poole,

    Affiliations: The Center for Molecular and Mitochondrial Medicine and Genetics (MAMMAG), University of California Irvine, Irvine, California, United States of America, Nanogen, Inc., San Diego, California, United States of America

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  • Sharine Wittkopp,

    Affiliation: The Center for Molecular and Mitochondrial Medicine and Genetics (MAMMAG), University of California Irvine, Irvine, California, United States of America

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  • Jeanette Feder,

    Affiliation: Department of Life Sciences and National Institute of Biotechnology (NIBN), Ben-Gurion University of the Negev, Beer-Sheva, Israel

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  • Timothy E. Shutt,

    Affiliation: Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Douglas C. Wallace,

    Affiliation: The Center for Molecular and Mitochondrial Medicine and Genetics (MAMMAG), University of California Irvine, Irvine, California, United States of America

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  • Gerald S. Shadel,

    Affiliation: Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Dan Mishmar mail

    dmishmar@bgu.ac.il

    Affiliation: Department of Life Sciences and National Institute of Biotechnology (NIBN), Ben-Gurion University of the Negev, Beer-Sheva, Israel

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  • Published: May 08, 2009
  • DOI: 10.1371/journal.pgen.1000474

About the Authors

Sarit Suissa, Jeanette Feder, Dan Mishmar
Department of Life Sciences and National Institute of Biotechnology (NIBN), Ben-Gurion University of the Negev, Beer-Sheva, Israel
Zhibo Wang, Timothy E. Shutt, Gerald S. Shadel
Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, United States of America
Jason Poole, Sharine Wittkopp, Douglas C. Wallace
The Center for Molecular and Mitochondrial Medicine and Genetics (MAMMAG), University of California Irvine, Irvine, California, United States of America
Jason Poole
Nanogen, Inc., San Diego, California, United States of America

Corresponding Author

Email: dmishmar@bgu.ac.il

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DM. Performed the experiments: SS ZW JP SW JF TES. Analyzed the data: SS ZW JP DCW GSS DM. Wrote the paper: DM. Performed the bioinformatics predictions and assisted in work design: SS. Performed the in vitro transcription and EMSA experiments: ZW. Performed the cybrid experiments: JP. Performed the cybrid experiments: SW. Screened and identified the samples pertaining to haplogroup J1, J1b and H: JF. Performed EMSA experiments: TES. Analysis of cybrid experiments and interpretation of the data: DCW. Analysis of in vitro transcription experiments and interpretation of the data: GSS.