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Research Article

DNA Methylation Analysis of Chromosome 21 Gene Promoters at Single Base Pair and Single Allele Resolution

  • Yingying Zhang equal contributor,

    equal contributor Contributed equally to this work with: Yingying Zhang, Christian Rohde, Sascha Tierling

    Affiliation: School of Engineering and Science, Jacobs University Bremen, Bremen, Germany

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  • Christian Rohde equal contributor,

    equal contributor Contributed equally to this work with: Yingying Zhang, Christian Rohde, Sascha Tierling

    Affiliation: School of Engineering and Science, Jacobs University Bremen, Bremen, Germany

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  • Sascha Tierling equal contributor,

    equal contributor Contributed equally to this work with: Yingying Zhang, Christian Rohde, Sascha Tierling

    Affiliation: Institut für Genetik, FB Biowissenschaften, Universität des Saarlandes, Saarbrücken, Germany

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  • Tomasz P. Jurkowski,

    Affiliation: School of Engineering and Science, Jacobs University Bremen, Bremen, Germany

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  • Christoph Bock,

    Affiliation: Max-Planck-Institut für Informatik, Saarbrücken, Germany

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  • Diana Santacruz,

    Affiliation: Institut für Genetik, FB Biowissenschaften, Universität des Saarlandes, Saarbrücken, Germany

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  • Sergey Ragozin,

    Affiliation: School of Engineering and Science, Jacobs University Bremen, Bremen, Germany

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  • Richard Reinhardt,

    Affiliation: Max Planck Institute for Molecular Genetics, Berlin-Dahlem, Germany

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  • Marco Groth,

    Affiliation: Leibniz-Institute for Age Research—Fritz-Lipmann-Institute, Jena, Germany

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  • Jörn Walter mail,

    j.walter@mx.uni-saarland.de (JW); a.jeltsch@jacobs-university.de (AJ)

    Affiliation: Institut für Genetik, FB Biowissenschaften, Universität des Saarlandes, Saarbrücken, Germany

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  • Albert Jeltsch mail

    j.walter@mx.uni-saarland.de (JW); a.jeltsch@jacobs-university.de (AJ)

    Affiliation: School of Engineering and Science, Jacobs University Bremen, Bremen, Germany

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  • Published: March 27, 2009
  • DOI: 10.1371/journal.pgen.1000438

About the Authors

Yingying Zhang, Christian Rohde, Tomasz P. Jurkowski, Sergey Ragozin, Albert Jeltsch
School of Engineering and Science, Jacobs University Bremen, Bremen, Germany
Sascha Tierling, Diana Santacruz, Jörn Walter
Institut für Genetik, FB Biowissenschaften, Universität des Saarlandes, Saarbrücken, Germany
Christoph Bock
Max-Planck-Institut für Informatik, Saarbrücken, Germany
Richard Reinhardt
Max Planck Institute for Molecular Genetics, Berlin-Dahlem, Germany
Marco Groth
Leibniz-Institute for Age Research—Fritz-Lipmann-Institute, Jena, Germany

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YZ CR ST SR RR JW AJ. Performed the experiments: YZ CR ST SR RR MG. Analyzed the data: YZ CR ST CB DS RR MG AJ. Contributed reagents/materials/analysis tools: TPJ CB RR. Wrote the paper: YZ CR ST CB JW AJ.