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Research Article

A Common Variant Associated with Dyslexia Reduces Expression of the KIAA0319 Gene

  • Megan Y. Dennis,

    Affiliations: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Silvia Paracchini,

    Affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • Thomas S. Scerri,

    Affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • Ludmila Prokunina-Olsson,

    Affiliation: Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Gaithersburg, Maryland, United States of America

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  • Julian C. Knight,

    Affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • Richard Wade-Martins,

    Affiliation: Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom

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  • Penny Coggill,

    Affiliation: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom

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  • Stephan Beck,

    Affiliation: UCL Cancer Institute, University College London, London, United Kingdom

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  • Eric D. Green mail,

    egreen@nhgri.nih.gov (EDG); anthony.monaco@well.ox.ac.uk (APM)

    Affiliation: Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Anthony P. Monaco mail

    egreen@nhgri.nih.gov (EDG); anthony.monaco@well.ox.ac.uk (APM)

    Affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • Published: March 27, 2009
  • DOI: 10.1371/journal.pgen.1000436

About the Authors

Megan Y. Dennis, Silvia Paracchini, Thomas S. Scerri, Julian C. Knight, Anthony P. Monaco
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
Megan Y. Dennis, Eric D. Green
Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
Ludmila Prokunina-Olsson
Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Gaithersburg, Maryland, United States of America
Richard Wade-Martins
Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom
Penny Coggill
Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom
Stephan Beck
UCL Cancer Institute, University College London, London, United Kingdom

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MYD SP TSS LPO JCK RWM EDG APM. Performed the experiments: MYD SP TSS LPO. Analyzed the data: MYD SP TSS LPO JCK RWM EDG APM. Contributed reagents/materials/analysis tools: MYD LPO RWM EDG APM. Wrote the paper: MYD SP LPO EDG APM. Made significant contributions to editing the paper: TSS JCK RWM. Sequenced the BACs: PC SB.