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Research Article

A Genome-Wide Association Study of Pulmonary Function Measures in the Framingham Heart Study

  • Jemma B. Wilk mail,

    jwilk@bu.edu

    Affiliation: Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America

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  • Ting-hsu Chen,

    Affiliations: Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America, The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America

    X
  • Daniel J. Gottlieb,

    Affiliations: Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America, The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America, Veteran's Affairs Boston Healthcare System, Boston, Massachusetts, United States of America

    X
  • Robert E. Walter,

    Affiliations: Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America, The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America

    X
  • Michael W. Nagle,

    Affiliation: Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America

    X
  • Brian J. Brandler,

    Affiliation: Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America

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  • Richard H. Myers,

    Affiliation: Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America

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  • Ingrid B. Borecki,

    Affiliation: Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Edwin K. Silverman,

    Affiliation: Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Scott T. Weiss,

    Affiliation: Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • George T. O'Connor

    Affiliations: Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America, The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America

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  • Published: March 20, 2009
  • DOI: 10.1371/journal.pgen.1000429

About the Authors

Jemma B. Wilk, Michael W. Nagle, Brian J. Brandler, Richard H. Myers
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America
Ting-hsu Chen, Daniel J. Gottlieb, Robert E. Walter, George T. O'Connor
Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America
Ting-hsu Chen, Daniel J. Gottlieb, Robert E. Walter, George T. O'Connor
The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America
Daniel J. Gottlieb
Veteran's Affairs Boston Healthcare System, Boston, Massachusetts, United States of America
Ingrid B. Borecki
Division of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, United States of America
Edwin K. Silverman, Scott T. Weiss
Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Corresponding Author

Email: jwilk@bu.edu

Competing Interests

EKS received an honorarium for a talk on COPD genetics in 2006, grant support for two studies of COPD genetics (2004–2008), and consulting fees (2006–2008) from GlaxoSmithKline. EKS received an honorarium from Wyeth for a talk on COPD genetics in 2004. EKS received an honorarium from Bayer for a symposium at the ERS Meeting in 2005. EKS received honoraria for talks in 2007 and 2008 and consulting fees in 2008 from AstraZeneca.

Author Contributions

Conceived and designed the experiments: JBW REW RHM EKS STW GTO. Performed the experiments: MWN BJB. Analyzed the data: JBW ThC DJG REW. Contributed reagents/materials/analysis tools: JBW RHM IBB. Wrote the paper: JBW ThC DJG REW RHM IBB EKS STW GTO.