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Research Article

Ciliary Beating Recovery in Deficient Human Airway Epithelial Cells after Lentivirus Ex Vivo Gene Therapy

  • Brigitte Chhin,

    Affiliation: Université de Lyon, Lyon, France

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  • Didier Negre,

    Affiliations: Université de Lyon (UCB-Lyon1), IFR128, Lyon, France, INSERM, U758, Lyon, France, Ecole Normale Supérieure de Lyon, Lyon, France

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  • Olivier Merrot,

    Affiliation: Hospices Civils de Lyon, Hôpital de la Croix-Rousse, Service ORL, Lyon, France

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  • Jacqueline Pham,

    Affiliation: Université de Lyon, Lyon, France

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  • Yves Tourneur,

    Affiliations: INSERM, UMR886, Cardioprotection, Lyon, France, Centre Commun de Quantimétrie, Université de Lyon, Lyon, France

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  • Denis Ressnikoff,

    Affiliation: Centre Commun de Quantimétrie, Université de Lyon, Lyon, France

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  • Martine Jaspers,

    Affiliation: Ear, Nose, and Throat Department, Head and Neck Surgery, Leuven, Belgium

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  • Mark Jorissen,

    Affiliation: Ear, Nose, and Throat Department, Head and Neck Surgery, Leuven, Belgium

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  • François-Loïc Cosset,

    Affiliations: Université de Lyon (UCB-Lyon1), IFR128, Lyon, France, INSERM, U758, Lyon, France, Ecole Normale Supérieure de Lyon, Lyon, France

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  • Patrice Bouvagnet mail

    patrice.bouvagnet@recherche.univ-lyon1.fr

    Affiliations: Université de Lyon, Lyon, France, Hospices Civils de Lyon, Groupe Hospitalier Est, Laboratoire Cardiogénétique, Bron, France, INSERM, CIC 201, Hôpital Louis Pradel, Bron, France

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  • Published: March 20, 2009
  • DOI: 10.1371/journal.pgen.1000422

About the Authors

Brigitte Chhin, Jacqueline Pham, Patrice Bouvagnet
Université de Lyon, Lyon, France
Didier Negre, François-Loïc Cosset
Université de Lyon (UCB-Lyon1), IFR128, Lyon, France
Didier Negre, François-Loïc Cosset
INSERM, U758, Lyon, France
Didier Negre, François-Loïc Cosset
Ecole Normale Supérieure de Lyon, Lyon, France
Olivier Merrot
Hospices Civils de Lyon, Hôpital de la Croix-Rousse, Service ORL, Lyon, France
Yves Tourneur
INSERM, UMR886, Cardioprotection, Lyon, France
Yves Tourneur, Denis Ressnikoff
Centre Commun de Quantimétrie, Université de Lyon, Lyon, France
Martine Jaspers, Mark Jorissen
Ear, Nose, and Throat Department, Head and Neck Surgery, Leuven, Belgium
Patrice Bouvagnet
Hospices Civils de Lyon, Groupe Hospitalier Est, Laboratoire Cardiogénétique, Bron, France
Patrice Bouvagnet
INSERM, CIC 201, Hôpital Louis Pradel, Bron, France

Corresponding Author

Email: patrice.bouvagnet@recherche.univ-lyon1.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: P. Bouvagnet. Performed the experiments: B. Chhin, D. Negre, J. Pham, M. Jaspers. Analyzed the data: B. Chhin, Y. Tourneur, D. Ressnikoff, M. Jorissen, P. Bouvagnet. Contributed reagents/materials/analysis tools: D. Negre, O. Merrot, Y. Tourneur, D. Ressnikoff, M. Jaspers, M. Jorissen, F-L. Cosset. Wrote the paper: B. Chhin, J. Pham, P. Bouvagnet.