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Research Article

A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci

  • Sreekumar G. Pillai mail,

    sreekumar.g.pillai@gsk.com (SGP); d.goldstein@duke.edu (DBG)

    Affiliation: Genetics Division, GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina, United States of America

    X
  • Dongliang Ge equal contributor,

    equal contributor Contributed equally to this work with: Dongliang Ge, Guohua Zhu, Xiangyang Kong

    Affiliation: IGSP Center for Population Genomics and Pharmacogenetics, Duke University, Durham, North Carolina, United States of America

    X
  • Guohua Zhu equal contributor,

    equal contributor Contributed equally to this work with: Dongliang Ge, Guohua Zhu, Xiangyang Kong

    Affiliation: Genetics Division, GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina, United States of America

    X
  • Xiangyang Kong equal contributor,

    equal contributor Contributed equally to this work with: Dongliang Ge, Guohua Zhu, Xiangyang Kong

    Affiliation: Genetics Division, GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina, United States of America

    X
  • Kevin V. Shianna,

    Affiliation: IGSP Center for Population Genomics and Pharmacogenetics, Duke University, Durham, North Carolina, United States of America

    X
  • Anna C. Need,

    Affiliation: IGSP Center for Population Genomics and Pharmacogenetics, Duke University, Durham, North Carolina, United States of America

    X
  • Sheng Feng,

    Affiliation: IGSP Center for Population Genomics and Pharmacogenetics, Duke University, Durham, North Carolina, United States of America

    X
  • Craig P. Hersh,

    Affiliation: Brigham and Women's Hospital, Boston, Massachusetts, United States of America

    X
  • Per Bakke,

    Affiliation: University of Bergen, Bergen, Norway

    X
  • Amund Gulsvik,

    Affiliation: University of Bergen, Bergen, Norway

    X
  • Andreas Ruppert,

    Affiliation: Genetics Research Centre, Munich, Germany

    X
  • Karin C. Lødrup Carlsen,

    Affiliation: Ullevaal University Hospital and the Faculty of Medicine, University of Oslo, Oslo, Norway

    X
  • Allen Roses,

    Affiliations: IGSP Center for Population Genomics and Pharmacogenetics, Duke University, Durham, North Carolina, United States of America, Deane Drug Discovery Institute, Duke University, Durham, North Carolina, United States of America

    X
  • Wayne Anderson,

    Affiliation: Genetics Division, GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina, United States of America

    X
  • ICGN Investigators,
  • Stephen I. Rennard,

    Affiliation: Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

    X
  • David A. Lomas,

    Affiliation: Cambridge Institute for Medical Research, Cambridge, United Kingdom

    X
  • Edwin K. Silverman,

    Affiliation: Brigham and Women's Hospital, Boston, Massachusetts, United States of America

    X
  • David B. Goldstein mail

    sreekumar.g.pillai@gsk.com (SGP); d.goldstein@duke.edu (DBG)

    Affiliation: IGSP Center for Population Genomics and Pharmacogenetics, Duke University, Durham, North Carolina, United States of America

    X
  • Published: March 20, 2009
  • DOI: 10.1371/journal.pgen.1000421

About the Authors

Sreekumar G. Pillai, Guohua Zhu, Xiangyang Kong, Wayne Anderson
Genetics Division, GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina, United States of America
Dongliang Ge, Kevin V. Shianna, Anna C. Need, Sheng Feng, Allen Roses, David B. Goldstein
IGSP Center for Population Genomics and Pharmacogenetics, Duke University, Durham, North Carolina, United States of America
Craig P. Hersh, Edwin K. Silverman
Brigham and Women's Hospital, Boston, Massachusetts, United States of America
Per Bakke, Amund Gulsvik
University of Bergen, Bergen, Norway
Andreas Ruppert
Genetics Research Centre, Munich, Germany
Karin C. Lødrup Carlsen
Ullevaal University Hospital and the Faculty of Medicine, University of Oslo, Oslo, Norway
Allen Roses
Deane Drug Discovery Institute, Duke University, Durham, North Carolina, United States of America
Stephen I. Rennard
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
David A. Lomas
Cambridge Institute for Medical Research, Cambridge, United Kingdom

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SGP PB AG KCLC AR WA SIR DAL EKS DBG. Performed the experiments: KVS ACN AR KCLC. Analyzed the data: DG GZ XK SF CPH. Wrote the paper: SGP EKS DBG.