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Research Article

Measures of Autozygosity in Decline: Globalization, Urbanization, and Its Implications for Medical Genetics

  • Michael A. Nalls,

    Affiliations: Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America, Laboratory of Epidemiology, Demography and Biometry, Intramural Research Program, National Institute on Aging, Maryland, United States of America

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  • Javier Simon-Sanchez,

    Affiliations: Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America, Unidad de Genética Molecular, Departamento de Genómica y Proteómica, Instituto de Biomedicina de Valencia-CSIC, Valencia, Spain

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  • J. Raphael Gibbs,

    Affiliations: Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America, Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, London, United Kingdom

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  • Coro Paisan-Ruiz,

    Affiliation: Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, London, United Kingdom

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  • Jose Tomas Bras,

    Affiliation: Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America

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  • Toshiko Tanaka,

    Affiliation: Longitudinal Studies Section, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America

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  • Mar Matarin,

    Affiliation: Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America

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  • Sonja Scholz,

    Affiliations: Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America, Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, London, United Kingdom

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  • Charles Weitz,

    Affiliation: Department of Anthropology, Biological Anthropology Program, Temple University, Philadelphia, Pennsylvania, United States of America

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  • Tamara B. Harris,

    Affiliation: Laboratory of Epidemiology, Demography and Biometry, Intramural Research Program, National Institute on Aging, Maryland, United States of America

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  • Luigi Ferrucci,

    Affiliation: Longitudinal Studies Section, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America

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  • John Hardy,

    Affiliation: Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, London, United Kingdom

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  • Andrew B. Singleton mail

    singleta@mail.nih.gov

    Affiliations: Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America, Department of Public Health Sciences, Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America

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  • Published: March 13, 2009
  • DOI: 10.1371/journal.pgen.1000415

About the Authors

Michael A. Nalls, Javier Simon-Sanchez, J. Raphael Gibbs, Jose Tomas Bras, Mar Matarin, Sonja Scholz, Andrew B. Singleton
Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America
Michael A. Nalls, Tamara B. Harris
Laboratory of Epidemiology, Demography and Biometry, Intramural Research Program, National Institute on Aging, Maryland, United States of America
Javier Simon-Sanchez
Unidad de Genética Molecular, Departamento de Genómica y Proteómica, Instituto de Biomedicina de Valencia-CSIC, Valencia, Spain
J. Raphael Gibbs, Coro Paisan-Ruiz, Sonja Scholz, John Hardy
Department of Molecular Neuroscience and Reta Lila Weston Laboratories, Institute of Neurology, London, United Kingdom
Toshiko Tanaka, Luigi Ferrucci
Longitudinal Studies Section, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America
Charles Weitz
Department of Anthropology, Biological Anthropology Program, Temple University, Philadelphia, Pennsylvania, United States of America
Andrew B. Singleton
Department of Public Health Sciences, Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America

Corresponding Author

Email: singleta@mail.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JH ABS. Performed the experiments: JSS CPR SS. Analyzed the data: MAN JSS JRG TT CW LF ABS. Contributed reagents/materials/analysis tools: JSS JTB TT MM CW TBH LF JH ABS. Wrote the paper: MAN JSS ABS.