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Research Article

Computationally Driven, Quantitative Experiments Discover Genes Required for Mitochondrial Biogenesis

  • David C. Hess,

    Affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America

    X
  • Chad L. Myers equal contributor,

    equal contributor Contributed equally to this work with: Chad L. Myers, Curtis Huttenhower, Matthew A. Hibbs

    Affiliations: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America, Department of Computer Science, Princeton University, Princeton, New Jersey, United States of America, Department of Computer Science and Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America

    X
  • Curtis Huttenhower equal contributor,

    equal contributor Contributed equally to this work with: Chad L. Myers, Curtis Huttenhower, Matthew A. Hibbs

    Affiliations: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America, Department of Computer Science, Princeton University, Princeton, New Jersey, United States of America

    X
  • Matthew A. Hibbs equal contributor,

    equal contributor Contributed equally to this work with: Chad L. Myers, Curtis Huttenhower, Matthew A. Hibbs

    Affiliations: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America, Department of Computer Science, Princeton University, Princeton, New Jersey, United States of America

    X
  • Alicia P. Hayes,

    Affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America

    X
  • Jadine Paw,

    Affiliation: Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada

    X
  • John J. Clore,

    Affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America

    X
  • Rosa M. Mendoza,

    Affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America

    X
  • Bryan San Luis,

    Affiliation: Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada

    X
  • Corey Nislow,

    Affiliation: Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada

    X
  • Guri Giaever,

    Affiliation: Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada

    X
  • Michael Costanzo,

    Affiliation: Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada

    X
  • Olga G. Troyanskaya mail,

    ogt@cs.princeton.edu (OGT); acaudy@princeton.edu (AAC)

    Affiliations: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America, Department of Computer Science, Princeton University, Princeton, New Jersey, United States of America

    X
  • Amy A. Caudy mail

    ogt@cs.princeton.edu (OGT); acaudy@princeton.edu (AAC)

    Affiliation: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America

    X
  • Published: March 20, 2009
  • DOI: 10.1371/journal.pgen.1000407

About the Authors

David C. Hess, Chad L. Myers, Curtis Huttenhower, Matthew A. Hibbs, Alicia P. Hayes, John J. Clore, Rosa M. Mendoza, Olga G. Troyanskaya, Amy A. Caudy
Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
Chad L. Myers, Curtis Huttenhower, Matthew A. Hibbs, Olga G. Troyanskaya
Department of Computer Science, Princeton University, Princeton, New Jersey, United States of America
Chad L. Myers
Department of Computer Science and Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America
Jadine Paw, Bryan San Luis, Corey Nislow, Guri Giaever, Michael Costanzo
Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DCH CLM CH MAH CN GG MC OGT AAC. Performed the experiments: DCH APH JP JJC RMM BSL MC AAC. Analyzed the data: DCH CLM CH MAH JJC AAC. Contributed reagents/materials/analysis tools: MC OGT AAC. Wrote the paper: DCH CLM CH MAH OGT AAC.