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Research Article

Destabilizing Protein Polymorphisms in the Genetic Background Direct Phenotypic Expression of Mutant SOD1 Toxicity

  • Tali Gidalevitz,

    Affiliation: Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois, United States of America

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  • Thomas Krupinski,

    Affiliation: Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois, United States of America

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  • Susana Garcia,

    Affiliation: Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois, United States of America

    Current address: Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Richard I. Morimoto mail

    r-morimoto@northwestern.edu

    Affiliation: Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois, United States of America

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  • Published: March 06, 2009
  • DOI: 10.1371/journal.pgen.1000399

About the Authors

Tali Gidalevitz, Thomas Krupinski, Susana Garcia, Richard I. Morimoto
Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois, United States of America

Corresponding Author

Email: r-morimoto@northwestern.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TG RIM. Performed the experiments: TG TK. Analyzed the data: TG. Contributed reagents/materials/analysis tools: TK SG. Wrote the paper: TG RIM.