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Research Article

Gene Dosage Effects of the Imprinted Delta-Like Homologue 1 (Dlk1/Pref1) in Development: Implications for the Evolution of Imprinting

  • Simao Teixeira da Rocha,

    Affiliation: Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom

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  • Marika Charalambous,

    Affiliation: Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom

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  • Shau-Ping Lin,

    Affiliation: Institute of Biotechnology, College of Bioresources and Agriculture, National Taiwan University, Taipei, Taiwan

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  • Isabel Gutteridge,

    Affiliation: Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom

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  • Yoko Ito,

    Affiliation: Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom

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  • Dionne Gray,

    Affiliation: Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom

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  • Wendy Dean,

    Affiliation: Developmental Genetics and Imprinting Laboratory, The Babraham Institute, Cambridge, United Kingdom

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  • Anne C. Ferguson-Smith mail

    afsmith@mole.bio.cam.ac.uk

    Affiliation: Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom

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  • Published: February 27, 2009
  • DOI: 10.1371/journal.pgen.1000392

About the Authors

Simao Teixeira da Rocha, Marika Charalambous, Isabel Gutteridge, Yoko Ito, Dionne Gray, Anne C. Ferguson-Smith
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom
Shau-Ping Lin
Institute of Biotechnology, College of Bioresources and Agriculture, National Taiwan University, Taipei, Taiwan
Wendy Dean
Developmental Genetics and Imprinting Laboratory, The Babraham Institute, Cambridge, United Kingdom

Corresponding Author

Email: afsmith@mole.bio.cam.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MC SPL ACFS. Performed the experiments: STdR MC SPL IG YI DG WD. Analyzed the data: STdR MC ACFS. Wrote the paper: STdR MC ACFS.