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Research Article

HECTD2 Is Associated with Susceptibility to Mouse and Human Prion Disease

  • Sarah E. Lloyd,

    Affiliations: MRC Prion Unit, University College London Institute of Neurology, London, United Kingdom, Department of Neurodegenerative Diseases, University College London Institute of Neurology, London, United Kingdom

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  • Emma G. Maytham,

    Affiliations: MRC Prion Unit, University College London Institute of Neurology, London, United Kingdom, Department of Neurodegenerative Diseases, University College London Institute of Neurology, London, United Kingdom

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  • Hirva Pota,

    Affiliations: MRC Prion Unit, University College London Institute of Neurology, London, United Kingdom, Department of Neurodegenerative Diseases, University College London Institute of Neurology, London, United Kingdom

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  • Julia Grizenkova,

    Affiliations: MRC Prion Unit, University College London Institute of Neurology, London, United Kingdom, Department of Neurodegenerative Diseases, University College London Institute of Neurology, London, United Kingdom

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  • Eleni Molou,

    Affiliations: MRC Prion Unit, University College London Institute of Neurology, London, United Kingdom, Department of Neurodegenerative Diseases, University College London Institute of Neurology, London, United Kingdom

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  • James Uphill,

    Affiliations: MRC Prion Unit, University College London Institute of Neurology, London, United Kingdom, Department of Neurodegenerative Diseases, University College London Institute of Neurology, London, United Kingdom

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  • Holger Hummerich,

    Affiliations: MRC Prion Unit, University College London Institute of Neurology, London, United Kingdom, Department of Neurodegenerative Diseases, University College London Institute of Neurology, London, United Kingdom

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  • Jerome Whitfield,

    Affiliations: MRC Prion Unit, University College London Institute of Neurology, London, United Kingdom, Department of Neurodegenerative Diseases, University College London Institute of Neurology, London, United Kingdom, Papua New Guinea Institute of Medical Research, Goroka, Eastern Highlands Province, Papua New Guinea

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  • Michael P. Alpers,

    Affiliations: MRC Prion Unit, University College London Institute of Neurology, London, United Kingdom, Department of Neurodegenerative Diseases, University College London Institute of Neurology, London, United Kingdom, Centre for International Health, Curtin University, Perth, Australia

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  • Simon Mead,

    Affiliations: MRC Prion Unit, University College London Institute of Neurology, London, United Kingdom, Department of Neurodegenerative Diseases, University College London Institute of Neurology, London, United Kingdom

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  • John Collinge mail

    j.collinge@prion.ucl.ac.uk

    Affiliations: MRC Prion Unit, University College London Institute of Neurology, London, United Kingdom, Department of Neurodegenerative Diseases, University College London Institute of Neurology, London, United Kingdom

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  • Published: February 13, 2009
  • DOI: 10.1371/journal.pgen.1000383

About the Authors

Sarah E. Lloyd, Emma G. Maytham, Hirva Pota, Julia Grizenkova, Eleni Molou, James Uphill, Holger Hummerich, Jerome Whitfield, Michael P. Alpers, Simon Mead, John Collinge
MRC Prion Unit, University College London Institute of Neurology, London, United Kingdom
Sarah E. Lloyd, Emma G. Maytham, Hirva Pota, Julia Grizenkova, Eleni Molou, James Uphill, Holger Hummerich, Jerome Whitfield, Michael P. Alpers, Simon Mead, John Collinge
Department of Neurodegenerative Diseases, University College London Institute of Neurology, London, United Kingdom
Jerome Whitfield
Papua New Guinea Institute of Medical Research, Goroka, Eastern Highlands Province, Papua New Guinea
Michael P. Alpers
Centre for International Health, Curtin University, Perth, Australia

Corresponding Author

Email: j.collinge@prion.ucl.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SEL JC. Performed the experiments: SEL EGM HP JG EM JU. Analyzed the data: SEL HH SM. Contributed reagents/materials/analysis tools: JW MPA. Wrote the paper: SEL JC.