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Research Article

Disease-Associated Mutant Ubiquitin Causes Proteasomal Impairment and Enhances the Toxicity of Protein Aggregates

  • Elizabeth M. H. Tank,

    Affiliation: Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Heather L. True mail

    htrue@cellbiology.wustl.edu

    Affiliation: Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Published: February 13, 2009
  • DOI: 10.1371/journal.pgen.1000382

About the Authors

Elizabeth M. H. Tank, Heather L. True
Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri, United States of America

Corresponding Author

Email: htrue@cellbiology.wustl.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EMHT HLT. Performed the experiments: EMHT. Analyzed the data: EMHT HLT. Wrote the paper: EMHT HLT.