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Research Article

LINE Retrotransposon RNA Is an Essential Structural and Functional Epigenetic Component of a Core Neocentromeric Chromatin

  • Anderly C. Chueh,

    Affiliation: Chromosome and Chromatin Research Laboratory, Murdoch Children's Research Institute, Melbourne University Department of Paediatrics, Royal Children's Hospital, Parkville, Victoria, Australia

    Current address: Ludwig Institute for Cancer Research, Austin Hospital, Heidelberg, Victoria, Australia

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  • Emma L. Northrop,

    Affiliation: Chromosome and Chromatin Research Laboratory, Murdoch Children's Research Institute, Melbourne University Department of Paediatrics, Royal Children's Hospital, Parkville, Victoria, Australia

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  • Kate H. Brettingham-Moore,

    Affiliation: Chromosome and Chromatin Research Laboratory, Murdoch Children's Research Institute, Melbourne University Department of Paediatrics, Royal Children's Hospital, Parkville, Victoria, Australia

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  • K. H. Andy Choo mail,

    andy.choo@mcri.edu.au (KHAC); lee.wong@mcri.edu.au (LHW)

    Affiliation: Chromosome and Chromatin Research Laboratory, Murdoch Children's Research Institute, Melbourne University Department of Paediatrics, Royal Children's Hospital, Parkville, Victoria, Australia

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  • Lee H. Wong mail

    andy.choo@mcri.edu.au (KHAC); lee.wong@mcri.edu.au (LHW)

    Affiliation: Chromosome and Chromatin Research Laboratory, Murdoch Children's Research Institute, Melbourne University Department of Paediatrics, Royal Children's Hospital, Parkville, Victoria, Australia

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  • Published: January 30, 2009
  • DOI: 10.1371/journal.pgen.1000354

About the Authors

Anderly C. Chueh, Emma L. Northrop, Kate H. Brettingham-Moore, K. H. Andy Choo, Lee H. Wong
Chromosome and Chromatin Research Laboratory, Murdoch Children's Research Institute, Melbourne University Department of Paediatrics, Royal Children's Hospital, Parkville, Victoria, Australia

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ACC LHW. Performed the experiments: ACC ELN LHW. Analyzed the data: ACC ELN LHW. Contributed reagents/materials/analysis tools: KHAC LHW. Wrote the paper: ACC LHW. Technical advice and discussion: ELN KHBM.