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Research Article

Mouse Genome-Wide Association Mapping Needs Linkage Analysis to Avoid False-Positive Loci

  • Giacomo Manenti,

    Affiliation: Department of Experimental Oncology and Laboratories, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

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  • Antonella Galvan,

    Affiliation: Department of Experimental Oncology and Laboratories, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

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  • Angela Pettinicchio,

    Affiliation: Department of Experimental Oncology and Laboratories, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

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  • Gaia Trincucci,

    Affiliation: Department of Experimental Oncology and Laboratories, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

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  • Elena Spada,

    Affiliation: Istituto di Statistica Medica e Biometria “GA Maccacaro”, Università di Milano, Milan, Italy

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  • Anna Zolin,

    Affiliation: Istituto di Statistica Medica e Biometria “GA Maccacaro”, Università di Milano, Milan, Italy

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  • Silvano Milani,

    Affiliation: Istituto di Statistica Medica e Biometria “GA Maccacaro”, Università di Milano, Milan, Italy

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  • Anna Gonzalez-Neira,

    Affiliation: Genotyping Unit (CeGen), CNIO, Madrid, Spain

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  • Tommaso A. Dragani mail

    tommaso.dragani@istitutotumori.mi.it

    Affiliation: Department of Experimental Oncology and Laboratories, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

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  • Published: January 09, 2009
  • DOI: 10.1371/journal.pgen.1000331

About the Authors

Giacomo Manenti, Antonella Galvan, Angela Pettinicchio, Gaia Trincucci, Tommaso A. Dragani
Department of Experimental Oncology and Laboratories, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
Elena Spada, Anna Zolin, Silvano Milani
Istituto di Statistica Medica e Biometria “GA Maccacaro”, Università di Milano, Milan, Italy
Anna Gonzalez-Neira
Genotyping Unit (CeGen), CNIO, Madrid, Spain

Corresponding Author

Email: tommaso.dragani@istitutotumori.mi.it

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GM TAD. Performed the experiments: GM AG AP GT. Analyzed the data: GM AG ES AZ SM TAD. Contributed reagents/materials/analysis tools: AGN. Wrote the paper: SM TAD.