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Research Article

Neuropeptide Y Gene Polymorphisms Confer Risk of Early-Onset Atherosclerosis

  • Svati H. Shah mail,

    svati.shah@duke.edu

    Affiliations: Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America, Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Neil J. Freedman,

    Affiliation: Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Lisheng Zhang,

    Affiliation: Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

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  • David R. Crosslin,

    Affiliation: Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, United States of America

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  • David H. Stone,

    Affiliation: Department of Surgery, Duke University, Durham, North Carolina, United States of America

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  • Carol Haynes,

    Affiliation: Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Jessica Johnson,

    Affiliation: Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Sarah Nelson,

    Affiliation: Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Liyong Wang,

    Affiliation: Miller School of Medicine, University of Miami, Miami, Florida, United States of America

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  • Jessica J. Connelly,

    Affiliation: Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Michael Muehlbauer,

    Affiliation: Sarah W. Stedman Center for Nutrition and Metabolism at Duke, Durham, North Carolina, United States of America

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  • Geoffrey S. Ginsburg,

    Affiliations: Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America, Duke Institute for Genome Sciences and Policy, Durham, North Carolina, United States of America

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  • David C. Crossman,

    Affiliation: University of Sheffield School of Medicine, Sheffield, United Kingdom

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  • Christopher J. H. Jones,

    Affiliation: The Wales Heart Research Institute, Cardiff, United Kingdom

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  • Jeffery Vance,

    Affiliation: Miller School of Medicine, University of Miami, Miami, Florida, United States of America

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  • Michael H. Sketch Jr,

    Affiliation: Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Christopher B. Granger,

    Affiliation: Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Christopher B. Newgard,

    Affiliation: Sarah W. Stedman Center for Nutrition and Metabolism at Duke, Durham, North Carolina, United States of America

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  • Simon G. Gregory,

    Affiliation: Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Pascal J. Goldschmidt-Clermont,

    Affiliation: Miller School of Medicine, University of Miami, Miami, Florida, United States of America

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  • William E. Kraus,

    Affiliation: Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Elizabeth R. Hauser

    Affiliation: Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Published: January 02, 2009
  • DOI: 10.1371/journal.pgen.1000318

About the Authors

Svati H. Shah, Neil J. Freedman, Lisheng Zhang, Geoffrey S. Ginsburg, Michael H. Sketch Jr, Christopher B. Granger, William E. Kraus
Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
Svati H. Shah, David R. Crosslin, Carol Haynes, Jessica Johnson, Sarah Nelson, Jessica J. Connelly, Simon G. Gregory, Elizabeth R. Hauser
Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, United States of America
David H. Stone
Department of Surgery, Duke University, Durham, North Carolina, United States of America
Liyong Wang, Jeffery Vance, Pascal J. Goldschmidt-Clermont
Miller School of Medicine, University of Miami, Miami, Florida, United States of America
Michael Muehlbauer, Christopher B. Newgard
Sarah W. Stedman Center for Nutrition and Metabolism at Duke, Durham, North Carolina, United States of America
Geoffrey S. Ginsburg
Duke Institute for Genome Sciences and Policy, Durham, North Carolina, United States of America
David C. Crossman
University of Sheffield School of Medicine, Sheffield, United Kingdom
Christopher J. H. Jones
The Wales Heart Research Institute, Cardiff, United Kingdom

Corresponding Author

Email: svati.shah@duke.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SHS NJF LZ DHS LW JJC GSG DCC CJHJ JV CBG SGG PJGC WEK ERH. Performed the experiments: SHS NJF LZ DRC DHS CH JJ SN LW MM CBN. Analyzed the data: SHS NJF LZ DRC CH JJ SN LW JJC MM SGG ERH. Contributed reagents/materials/analysis tools: SHS NJF MM DCC MHSJ. Wrote the paper: SHS NJF DRC DHS CH SN LW JJC GSG CBG CBN PJGC WEK ERH.