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Research Article

Physcomitrella patens DCL3 Is Required for 22–24 nt siRNA Accumulation, Suppression of Retrotransposon-Derived Transcripts, and Normal Development

  • Sung Hyun Cho,

    Affiliation: Department of Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America

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  • Charles Addo-Quaye,

    Affiliation: Department of Computer Science and Engineering, Pennsylvania State University, University Park, Pennsylvania, United States of America

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  • Ceyda Coruh,

    Affiliation: Plant Biology Graduate Program, Pennsylvania State University, University Park, Pennsylvania, United States of America

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  • M. Asif Arif,

    Affiliation: Plant Biotechnology, Faculty of Biology, University of Freiburg, Freiburg, Germany

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  • Zhaorong Ma,

    Affiliation: Integrative Biosciences Graduate Program in Bioinformatics and Genomics, Pennsylvania State University, University Park, Pennsylvania, United States of America

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  • Wolfgang Frank,

    Affiliation: Plant Biotechnology, Faculty of Biology, University of Freiburg, Freiburg, Germany

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  • Michael J. Axtell mail

    mja18@psu.edu

    Affiliations: Department of Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America, Plant Biology Graduate Program, Pennsylvania State University, University Park, Pennsylvania, United States of America, Integrative Biosciences Graduate Program in Bioinformatics and Genomics, Pennsylvania State University, University Park, Pennsylvania, United States of America

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  • Published: December 19, 2008
  • DOI: 10.1371/journal.pgen.1000314

About the Authors

Sung Hyun Cho, Michael J. Axtell
Department of Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America
Charles Addo-Quaye
Department of Computer Science and Engineering, Pennsylvania State University, University Park, Pennsylvania, United States of America
Ceyda Coruh, Michael J. Axtell
Plant Biology Graduate Program, Pennsylvania State University, University Park, Pennsylvania, United States of America
M. Asif Arif, Wolfgang Frank
Plant Biotechnology, Faculty of Biology, University of Freiburg, Freiburg, Germany
Zhaorong Ma, Michael J. Axtell
Integrative Biosciences Graduate Program in Bioinformatics and Genomics, Pennsylvania State University, University Park, Pennsylvania, United States of America

Corresponding Author

Email: mja18@psu.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SHC CAQ WF MJA. Performed the experiments: SHC CAQ CC MAA. Analyzed the data: SHC CAQ WF MJA. Contributed reagents/materials/analysis tools: ZM. Wrote the paper: SHC MJA.