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Research Article

Genome-Wide siRNA-Based Functional Genomics of Pigmentation Identifies Novel Genes and Pathways That Impact Melanogenesis in Human Cells

  • Anand K. Ganesan equal contributor mail,

    equal contributor Contributed equally to this work with: Anand K. Ganesan, Hsiang Ho

    aganesan@uci.edu (AKG); michael.white@utsouthwestern.edu (MAW)

    Affiliations: Department of Dermatology, University of California Irvine, Irvine, California, United States of America, Department of Biological Chemistry, University of California Irvine, Irvine, California, United States of America

    X
  • Hsiang Ho equal contributor,

    equal contributor Contributed equally to this work with: Anand K. Ganesan, Hsiang Ho

    Affiliation: Department of Biological Chemistry, University of California Irvine, Irvine, California, United States of America

    X
  • Brian Bodemann,

    Affiliation: Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

    X
  • Sean Petersen,

    Affiliation: Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

    X
  • Jayavani Aruri,

    Affiliation: Department of Dermatology, University of California Irvine, Irvine, California, United States of America

    X
  • Shiney Koshy,

    Affiliation: Department of Dermatology, University of California Irvine, Irvine, California, United States of America

    X
  • Zachary Richardson,

    Affiliation: Department of Dermatology, University of California Irvine, Irvine, California, United States of America

    X
  • Lu Q. Le,

    Affiliation: Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

    X
  • Tatiana Krasieva,

    Affiliation: Beckman Laser Institute, University of California Irvine, Irvine, California, United States of America

    X
  • Michael G. Roth,

    Affiliation: Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

    X
  • Pat Farmer,

    Affiliation: Department of Chemistry, University of California Irvine, Irvine, California, United States of America

    X
  • Michael A. White mail

    aganesan@uci.edu (AKG); michael.white@utsouthwestern.edu (MAW)

    Affiliation: Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

    X
  • Published: December 05, 2008
  • DOI: 10.1371/journal.pgen.1000298

About the Authors

Anand K. Ganesan, Jayavani Aruri, Shiney Koshy, Zachary Richardson
Department of Dermatology, University of California Irvine, Irvine, California, United States of America
Anand K. Ganesan, Hsiang Ho
Department of Biological Chemistry, University of California Irvine, Irvine, California, United States of America
Brian Bodemann, Michael A. White
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
Sean Petersen, Michael G. Roth
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
Lu Q. Le
Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
Tatiana Krasieva
Beckman Laser Institute, University of California Irvine, Irvine, California, United States of America
Pat Farmer
Department of Chemistry, University of California Irvine, Irvine, California, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AKG MAW. Performed the experiments: AKG HH BB SP JA SK ZR LQL. Analyzed the data: AKG TK MAW. Contributed reagents/materials/analysis tools: AKG MGR PF MAW. Wrote the paper: AKG MAW.