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Research Article

Effects of cis and trans Genetic Ancestry on Gene Expression in African Americans

  • Alkes L. Price mail,

    aprice@hsph.harvard.edu (ALP); spielman@pobox.upenn.edu (RSS)

    Affiliations: Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America, Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Nick Patterson,

    Affiliation: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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  • Dustin C. Hancks,

    Affiliation: Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Simon Myers,

    Affiliation: Department of Statistics, University of Oxford, Oxford, United Kingdom

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  • David Reich,

    Affiliations: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Vivian G. Cheung,

    Affiliations: Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Pediatrics, University of Pennsylvania School of Medicine, Pennsylvania, United States of America, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Howard Hughes Medical Institute, Philadelphia, Pennsylvania, United States of America

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  • Richard S. Spielman mail

    aprice@hsph.harvard.edu (ALP); spielman@pobox.upenn.edu (RSS)

    Affiliation: Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Published: December 05, 2008
  • DOI: 10.1371/journal.pgen.1000294

About the Authors

Alkes L. Price
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
Alkes L. Price
Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America
Nick Patterson, David Reich
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
Dustin C. Hancks, Vivian G. Cheung, Richard S. Spielman
Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
Simon Myers
Department of Statistics, University of Oxford, Oxford, United Kingdom
David Reich
Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
Vivian G. Cheung
Department of Pediatrics, University of Pennsylvania School of Medicine, Pennsylvania, United States of America
Vivian G. Cheung
The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
Vivian G. Cheung
Howard Hughes Medical Institute, Philadelphia, Pennsylvania, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ALP NP DR VGC RSS. Performed the experiments: DCH VGC RSS. Analyzed the data: ALP NP SM DR VGC RSS. Wrote the paper: ALP DR VGC RSS. Contributed data: DCH VGC RSS.