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Research Article

The Genomic Analysis of Lactic Acidosis and Acidosis Response in Human Cancers

  • Julia Ling-Yu Chen,

    Affiliations: Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America, Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States of America

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  • Joseph E. Lucas,

    Affiliation: Department of Statistical Science, Duke University, Durham, North Carolina, United States of America

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  • Thies Schroeder,

    Affiliation: Department of Radiation Oncology, Duke University, Durham, North Carolina, United States of America

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  • Seiichi Mori,

    Affiliations: Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America, Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States of America

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  • Jianli Wu,

    Affiliations: Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America, Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States of America

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  • Joseph Nevins,

    Affiliations: Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America, Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States of America

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  • Mark Dewhirst,

    Affiliation: Department of Radiation Oncology, Duke University, Durham, North Carolina, United States of America

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  • Mike West,

    Affiliation: Department of Statistical Science, Duke University, Durham, North Carolina, United States of America

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  • Jen-Tsan Chi mail

    chi00002@mc.duke.edu

    Affiliations: Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America, Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States of America

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  • Published: December 05, 2008
  • DOI: 10.1371/journal.pgen.1000293

About the Authors

Julia Ling-Yu Chen, Seiichi Mori, Jianli Wu, Joseph Nevins, Jen-Tsan Chi
Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America
Julia Ling-Yu Chen, Seiichi Mori, Jianli Wu, Joseph Nevins, Jen-Tsan Chi
Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States of America
Joseph E. Lucas, Mike West
Department of Statistical Science, Duke University, Durham, North Carolina, United States of America
Thies Schroeder, Mark Dewhirst
Department of Radiation Oncology, Duke University, Durham, North Carolina, United States of America

Corresponding Author

Email: chi00002@mc.duke.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JLYC MW JTC. Performed the experiments: JLYC TS JW JTC. Analyzed the data: JLYC JEL SM JN MD MW JTC. Contributed reagents/materials/analysis tools: JEL JTC. Wrote the paper: JLYC JEL JN MW JTC.