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Research Article

Genetic Analysis of Human Traits In Vitro: Drug Response and Gene Expression in Lymphoblastoid Cell Lines

  • Edwin Choy equal contributor,

    equal contributor Contributed equally to this work with: Edwin Choy, Roman Yelensky

    Affiliations: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Division of Hematology Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

    X
  • Roman Yelensky equal contributor,

    equal contributor Contributed equally to this work with: Edwin Choy, Roman Yelensky

    Affiliations: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard–MIT Division of Health Sciences and Technology, Cambridge, Massachusetts, United States of America

    X
  • Sasha Bonakdar,

    Affiliation: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

    X
  • Robert M. Plenge,

    Affiliations: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

    X
  • Richa Saxena,

    Affiliations: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

    X
  • Philip L. De Jager,

    Affiliations: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, Harvard Medical School–Partners Healthcare Center for Genetics and Genomics, Boston, Massachusetts, United States of America

    X
  • Stanley Y. Shaw,

    Affiliations: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Systems Biology and Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America

    X
  • Cara S. Wolfish,

    Affiliations: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

    X
  • Jacqueline M. Slavik,

    Affiliations: Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Biomedical Research Institute, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

    X
  • Chris Cotsapas,

    Affiliations: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Manuel Rivas,

    Affiliations: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Department of Mathematics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United Sates of America

    X
  • Emmanouil T. Dermitzakis,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom

    X
  • Ellen Cahir-McFarland,

    Affiliations: Harvard Medical School, Boston, Massachusetts, United States of America, Channing Laboratory and Infectious Disease Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

    X
  • Elliott Kieff,

    Affiliations: Harvard Medical School, Boston, Massachusetts, United States of America, Channing Laboratory and Infectious Disease Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

    X
  • David Hafler,

    Affiliations: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

    X
  • Mark J. Daly,

    Affiliations: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • David Altshuler mail

    altshuler@molbio.mgh.harvard.edu

    Affiliations: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America

    X
  • Published: November 28, 2008
  • DOI: 10.1371/journal.pgen.1000287

About the Authors

Edwin Choy, Roman Yelensky, Sasha Bonakdar, Robert M. Plenge, Richa Saxena, Philip L. De Jager, Stanley Y. Shaw, Cara S. Wolfish, Chris Cotsapas, Manuel Rivas, David Hafler, Mark J. Daly, David Altshuler
Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
Edwin Choy, Roman Yelensky, Robert M. Plenge, Richa Saxena, Chris Cotsapas, Mark J. Daly, David Altshuler
Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Edwin Choy
Division of Hematology Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Edwin Choy, Roman Yelensky, Robert M. Plenge, Richa Saxena, David Altshuler
Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Roman Yelensky
Harvard–MIT Division of Health Sciences and Technology, Cambridge, Massachusetts, United States of America
Robert M. Plenge
Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
Philip L. De Jager, Cara S. Wolfish, Jacqueline M. Slavik, David Hafler
Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
Philip L. De Jager, Stanley Y. Shaw, Ellen Cahir-McFarland, Elliott Kieff
Harvard Medical School, Boston, Massachusetts, United States of America
Philip L. De Jager
Harvard Medical School–Partners Healthcare Center for Genetics and Genomics, Boston, Massachusetts, United States of America
Stanley Y. Shaw
Center for Systems Biology and Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Jacqueline M. Slavik
Biomedical Research Institute, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
Chris Cotsapas, Mark J. Daly, David Altshuler
Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
Manuel Rivas
Department of Mathematics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United Sates of America
Emmanouil T. Dermitzakis
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom
Ellen Cahir-McFarland, Elliott Kieff
Channing Laboratory and Infectious Disease Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
David Altshuler
Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
David Altshuler
Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Corresponding Author

Email: altshuler@molbio.mgh.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EC RY SB SYS ECM EK DH MJD DA. Performed the experiments: EC SB RMP RS PLDJ CSW JMS. Analyzed the data: EC RY MJD DA. Contributed reagents/materials/analysis tools: RY CC MR ETD. Wrote the paper: EC RY MJD DA. Jointly supervised the project: MJD DA.