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Research Article

Field-Caught Permethrin-Resistant Anopheles gambiae Overexpress CYP6P3, a P450 That Metabolises Pyrethroids

  • Pie Müller equal contributor mail,

    equal contributor Contributed equally to this work with: Pie Müller, Emma Warr, Bradley J. Stevenson

    pie.muller@liv.ac.uk

    Affiliation: Vector Group, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

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  • Emma Warr equal contributor,

    equal contributor Contributed equally to this work with: Pie Müller, Emma Warr, Bradley J. Stevenson

    Affiliation: Vector Group, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

    Current address: Centre for Applied Entomology and Parasitology, School of Life Sciences, Keele University, Staffordshire, United Kingdom

    X
  • Bradley J. Stevenson equal contributor,

    equal contributor Contributed equally to this work with: Pie Müller, Emma Warr, Bradley J. Stevenson

    Affiliation: Vector Group, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

    X
  • Patricia M. Pignatelli,

    Affiliation: Vector Group, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

    X
  • John C. Morgan,

    Affiliation: Vector Group, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

    X
  • Andrew Steven,

    Affiliation: Vector Group, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

    X
  • Alexander E. Yawson,

    Affiliation: Biotechnology and Nuclear Agricultural Research Institute, Ghana Atomic Energy Commission, Kwabenya, Accra, Ghana

    X
  • Sara N. Mitchell,

    Affiliation: Vector Group, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

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  • Hilary Ranson,

    Affiliation: Vector Group, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

    X
  • Janet Hemingway,

    Affiliation: Vector Group, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

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  • Mark J. I. Paine,

    Affiliation: Vector Group, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

    X
  • Martin J. Donnelly

    Affiliation: Vector Group, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

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  • Published: November 28, 2008
  • DOI: 10.1371/journal.pgen.1000286

About the Authors

Pie Müller, Emma Warr, Bradley J. Stevenson, Patricia M. Pignatelli, John C. Morgan, Andrew Steven, Sara N. Mitchell, Hilary Ranson, Janet Hemingway, Mark J. I. Paine, Martin J. Donnelly
Vector Group, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
Alexander E. Yawson
Biotechnology and Nuclear Agricultural Research Institute, Ghana Atomic Energy Commission, Kwabenya, Accra, Ghana

Corresponding Author

Email: pie.muller@liv.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PM EW BJS PMP MJIP MJD. Performed the experiments: PM EW BJS PMP JCM AS SNM MJD. Analyzed the data: PM EW BJS. Contributed reagents/materials/analysis tools: AEY. Wrote the paper: PM EW BJS HR JH MJIP MJD. Oversaw experimental design and analysis: HR MJIP MJD.