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Research Article

Chemical–Genetic Profiling of Imidazo[1,2-a]pyridines and -Pyrimidines Reveals Target Pathways Conserved between Yeast and Human Cells

  • Lisa Yu equal contributor,

    equal contributor Contributed equally to this work with: Lisa Yu, Andres Lopez

    Affiliations: Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada

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  • Andres Lopez equal contributor,

    equal contributor Contributed equally to this work with: Lisa Yu, Andres Lopez

    Affiliations: Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

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  • Abderrahmane Anaflous,

    Affiliation: Laboratoire de Chimie du Solide Minéral et Analytique, Département de Chimie, Faculté des Sciences, Université Mohamed Premier, Oujda, Morocco

    X
  • Brahim El Bali,

    Affiliation: Laboratoire de Chimie du Solide Minéral et Analytique, Département de Chimie, Faculté des Sciences, Université Mohamed Premier, Oujda, Morocco

    X
  • Abdellah Hamal,

    Affiliation: Laboratoire de Génétique et Biotechnologies, Département de Biologie, Faculté des Sciences, Université Mohamed Premier, Oujda, Morocco

    X
  • Elke Ericson,

    Affiliations: Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

    X
  • Lawrence E. Heisler,

    Affiliations: Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada

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  • Angus McQuibban,

    Affiliation: Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada

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  • Guri Giaever,

    Affiliations: Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada

    X
  • Corey Nislow,

    Affiliations: Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

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  • Charles Boone,

    Affiliations: Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

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  • Grant W. Brown mail,

    grant.brown@utoronto.ca (GWB); bmbellaoui@gmail.com (MB)

    Affiliations: Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada

    X
  • Mohammed Bellaoui mail

    grant.brown@utoronto.ca (GWB); bmbellaoui@gmail.com (MB)

    Affiliations: Laboratoire de Génétique et Biotechnologies, Département de Biologie, Faculté des Sciences, Université Mohamed Premier, Oujda, Morocco, Faculté Pluridisciplinaire de Nador, Université Mohamed Premier, Nador, Morocco

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  • Published: November 28, 2008
  • DOI: 10.1371/journal.pgen.1000284

About the Authors

Lisa Yu, Angus McQuibban, Grant W. Brown
Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
Lisa Yu, Andres Lopez, Elke Ericson, Lawrence E. Heisler, Guri Giaever, Corey Nislow, Charles Boone, Grant W. Brown
Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada
Andres Lopez, Elke Ericson, Corey Nislow, Charles Boone
Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada
Andres Lopez, Elke Ericson, Guri Giaever, Corey Nislow, Charles Boone
Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
Abderrahmane Anaflous, Brahim El Bali
Laboratoire de Chimie du Solide Minéral et Analytique, Département de Chimie, Faculté des Sciences, Université Mohamed Premier, Oujda, Morocco
Abdellah Hamal, Mohammed Bellaoui
Laboratoire de Génétique et Biotechnologies, Département de Biologie, Faculté des Sciences, Université Mohamed Premier, Oujda, Morocco
Lawrence E. Heisler, Guri Giaever
Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
Mohammed Bellaoui
Faculté Pluridisciplinaire de Nador, Université Mohamed Premier, Nador, Morocco

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LY AL AM CN CB GWB MB. Performed the experiments: LY AL EE MB. Analyzed the data: LY AL LEH AM CN CB GWB MB. Contributed reagents/materials/analysis tools: AA BEB AH AM GG CN. Wrote the paper: LY AL CN GWB MB.