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Research Article

A Role for Oxidized DNA Precursors in Huntington's Disease–Like Striatal Neurodegeneration

  • Gabriele De Luca equal contributor,

    equal contributor Contributed equally to this work with: Gabriele De Luca, Maria Teresa Russo

    Affiliation: Department of Environment and Primary Prevention, Experimental Carcinogenesis Division, Istituto Superiore di Sanità, Rome, Italy

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  • Maria Teresa Russo equal contributor,

    equal contributor Contributed equally to this work with: Gabriele De Luca, Maria Teresa Russo

    Affiliation: Department of Environment and Primary Prevention, Experimental Carcinogenesis Division, Istituto Superiore di Sanità, Rome, Italy

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  • Paolo Degan,

    Affiliation: Department of Translational Oncology, Istituto Nazionale per la Ricerca sul Cancro (IST-CBA), Genova, Italy

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  • Cecilia Tiveron,

    Affiliation: European Brain Research Institute, Rome, Italy

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  • Andrea Zijno,

    Affiliation: Department of Environment and Primary Prevention, Experimental Carcinogenesis Division, Istituto Superiore di Sanità, Rome, Italy

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  • Ettore Meccia,

    Affiliation: Department of Environment and Primary Prevention, Experimental Carcinogenesis Division, Istituto Superiore di Sanità, Rome, Italy

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  • Ilenia Ventura,

    Affiliation: Department of Environment and Primary Prevention, Experimental Carcinogenesis Division, Istituto Superiore di Sanità, Rome, Italy

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  • Elisabetta Mattei,

    Affiliation: Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy

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  • Yusaku Nakabeppu,

    Affiliation: Division of Neurofunctional Genomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan

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  • Marco Crescenzi,

    Affiliation: Department of Environment and Primary Prevention, Experimental Carcinogenesis Division, Istituto Superiore di Sanità, Rome, Italy

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  • Rita Pepponi,

    Affiliation: Department of Drug Research and Evaluation, Central Nervous System Pharmacology Division, Istituto Superiore di Sanità, Rome, Italy

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  • Antonella Pèzzola,

    Affiliation: Department of Drug Research and Evaluation, Central Nervous System Pharmacology Division, Istituto Superiore di Sanità, Rome, Italy

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  • Patrizia Popoli,

    Affiliation: Department of Drug Research and Evaluation, Central Nervous System Pharmacology Division, Istituto Superiore di Sanità, Rome, Italy

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  • Margherita Bignami mail

    bignami@iss.it

    Affiliation: Department of Environment and Primary Prevention, Experimental Carcinogenesis Division, Istituto Superiore di Sanità, Rome, Italy

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  • Published: November 21, 2008
  • DOI: 10.1371/journal.pgen.1000266

About the Authors

Gabriele De Luca, Maria Teresa Russo, Andrea Zijno, Ettore Meccia, Ilenia Ventura, Marco Crescenzi, Margherita Bignami
Department of Environment and Primary Prevention, Experimental Carcinogenesis Division, Istituto Superiore di Sanità, Rome, Italy
Paolo Degan
Department of Translational Oncology, Istituto Nazionale per la Ricerca sul Cancro (IST-CBA), Genova, Italy
Cecilia Tiveron
European Brain Research Institute, Rome, Italy
Elisabetta Mattei
Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy
Yusaku Nakabeppu
Division of Neurofunctional Genomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
Rita Pepponi, Antonella Pèzzola, Patrizia Popoli
Department of Drug Research and Evaluation, Central Nervous System Pharmacology Division, Istituto Superiore di Sanità, Rome, Italy

Corresponding Author

Email: bignami@iss.it

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MC PP MB. Performed the experiments: GDL MTR PD CT AZ EM IV EM RP AP. Analyzed the data: MTR PD MC. Contributed reagents/materials/analysis tools: YN. Wrote the paper: MB.