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Research Article

Hypermutability of Damaged Single-Strand DNA Formed at Double-Strand Breaks and Uncapped Telomeres in Yeast Saccharomyces cerevisiae

  • Yong Yang,

    Affiliation: Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, United States of America

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  • Joan Sterling,

    Affiliation: Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, United States of America

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  • Francesca Storici,

    Affiliation: Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, United States of America

    Current address: School of Biology, Georgia Institute of Technology, Atlanta, Georgia, United States of America

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  • Michael A. Resnick mail,

    resnick@niehs.nih.gov (MAR); gordenin@niehs.nih.gov (DAG)

    Affiliation: Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, United States of America

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  • Dmitry A. Gordenin mail

    resnick@niehs.nih.gov (MAR); gordenin@niehs.nih.gov (DAG)

    Affiliation: Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, United States of America

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  • Published: November 21, 2008
  • DOI: 10.1371/journal.pgen.1000264

About the Authors

Yong Yang, Joan Sterling, Francesca Storici, Michael A. Resnick, Dmitry A. Gordenin
Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YY FS MAR DAG. Performed the experiments: YY JS DAG. Analyzed the data: YY JS FS MAR DAG. Contributed reagents/materials/analysis tools: YY JS FS. Wrote the paper: YY MAR DAG. Conceived the idea: DAG.