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Research Article

Functional Polymorphisms in PRODH Are Associated with Risk and Protection for Schizophrenia and Fronto-Striatal Structure and Function

  • Lucas Kempf,

    Affiliations: Unit of Systems Neuroscience in Psychiatry, National Institute of Mental Health, Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland, United States of America, Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Kristin K. Nicodemus,

    Affiliation: Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland, United States of America

    Current address: Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom

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  • Bhaskar Kolachana,

    Affiliation: Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Radhakrishna Vakkalanka,

    Affiliation: Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Beth A. Verchinski,

    Affiliations: Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland, United States of America, Neuroimaging Core Facility, National Institute of Mental Health, Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Michael F. Egan,

    Affiliation: Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland, United States of America

    Current address: Merck & Co, Inc., West Point, Pennsylvania, United States of America

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  • Richard E. Straub,

    Affiliation: Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Venkata A. Mattay,

    Affiliations: Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland, United States of America, Neuroimaging Core Facility, National Institute of Mental Health, Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Joseph H. Callicott,

    Affiliation: Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Daniel R. Weinberger mail,

    weinberd@mail.nih.gov (DRW); a.meyer-lindenberg@zi-mannheim.de (AML)

    Affiliation: Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Andreas Meyer-Lindenberg mail

    weinberd@mail.nih.gov (DRW); a.meyer-lindenberg@zi-mannheim.de (AML)

    Affiliations: Unit of Systems Neuroscience in Psychiatry, National Institute of Mental Health, Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland, United States of America, Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland, United States of America, Neuroimaging Core Facility, National Institute of Mental Health, Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland, United States of America, Central Institute of Mental Health, Mannheim, Germany

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  • Published: November 07, 2008
  • DOI: 10.1371/journal.pgen.1000252

About the Authors

Lucas Kempf, Andreas Meyer-Lindenberg
Unit of Systems Neuroscience in Psychiatry, National Institute of Mental Health, Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland, United States of America
Lucas Kempf, Kristin K. Nicodemus, Bhaskar Kolachana, Radhakrishna Vakkalanka, Beth A. Verchinski, Michael F. Egan, Richard E. Straub, Venkata A. Mattay, Joseph H. Callicott, Daniel R. Weinberger, Andreas Meyer-Lindenberg
Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland, United States of America
Beth A. Verchinski, Venkata A. Mattay, Andreas Meyer-Lindenberg
Neuroimaging Core Facility, National Institute of Mental Health, Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland, United States of America
Andreas Meyer-Lindenberg
Central Institute of Mental Health, Mannheim, Germany

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LK MFE VAM JHC DRW. Performed the experiments: LK BK RV BAV RES VAM JHC. Analyzed the data: LK KKN BK RV BAV MFE RES AML. Contributed reagents/materials/analysis tools: KKN BK RV BAV MFE RES VAM JHC DRW AML. Wrote the paper: LK KKN DRW AML.