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Research Article

The Novel Mouse Mutation Oblivion Inactivates the PMCA2 Pump and Causes Progressive Hearing Loss

  • Sarah L. Spiden equal contributor,

    equal contributor Contributed equally to this work with: Sarah L. Spiden, Mario Bortolozzi, Francesca Di Leva

    Affiliations: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom, MRC Institute of Hearing Research, University Park, Nottingham, United Kingdom

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  • Mario Bortolozzi equal contributor,

    equal contributor Contributed equally to this work with: Sarah L. Spiden, Mario Bortolozzi, Francesca Di Leva

    Affiliation: Venetian Institute of Molecular Medicine (VIMM), Padua, Italy

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  • Francesca Di Leva equal contributor,

    equal contributor Contributed equally to this work with: Sarah L. Spiden, Mario Bortolozzi, Francesca Di Leva

    Affiliation: Department of Biochemistry and Department of Experimental Veterinary Sciences, University of Padua, Padua, Italy

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  • Martin Hrabé de Angelis,

    Affiliation: Helmholtz Zentrum München, Institute of Experimental Genetics, Neuherberg, Germany

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  • Helmut Fuchs,

    Affiliation: Helmholtz Zentrum München, Institute of Experimental Genetics, Neuherberg, Germany

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  • Dmitry Lim,

    Affiliation: Venetian Institute of Molecular Medicine (VIMM), Padua, Italy

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  • Saida Ortolano,

    Affiliation: Venetian Institute of Molecular Medicine (VIMM), Padua, Italy

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  • Neil J. Ingham,

    Affiliation: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom

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  • Marisa Brini,

    Affiliation: Department of Biochemistry and Department of Experimental Veterinary Sciences, University of Padua, Padua, Italy

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  • Ernesto Carafoli,

    Affiliation: Venetian Institute of Molecular Medicine (VIMM), Padua, Italy

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  • Fabio Mammano,

    Affiliations: Venetian Institute of Molecular Medicine (VIMM), Padua, Italy, Department of Physics, University of Padua, Padua, Italy

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  • Karen P. Steel mail

    kps@sanger.ac.uk

    Affiliations: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom, MRC Institute of Hearing Research, University Park, Nottingham, United Kingdom

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  • Published: October 31, 2008
  • DOI: 10.1371/journal.pgen.1000238

About the Authors

Sarah L. Spiden, Neil J. Ingham, Karen P. Steel
Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, United Kingdom
Sarah L. Spiden, Karen P. Steel
MRC Institute of Hearing Research, University Park, Nottingham, United Kingdom
Mario Bortolozzi, Dmitry Lim, Saida Ortolano, Ernesto Carafoli, Fabio Mammano
Venetian Institute of Molecular Medicine (VIMM), Padua, Italy
Francesca Di Leva, Marisa Brini
Department of Biochemistry and Department of Experimental Veterinary Sciences, University of Padua, Padua, Italy
Martin Hrabé de Angelis, Helmut Fuchs
Helmholtz Zentrum München, Institute of Experimental Genetics, Neuherberg, Germany
Fabio Mammano
Department of Physics, University of Padua, Padua, Italy

Corresponding Author

Email: kps@sanger.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SLS MB FDL DL SO NJI MB EC FM KPS. Performed the experiments: SLS MB FDL DL SO NJI. Analyzed the data: SLS MHdA HF NJI MB EC FM KPS. Contributed reagents/materials/analysis tools: MHdA HF. Wrote the paper: SLS NJI MB EC FM KPS.