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Research Article

Evolution and Dynamics of Regulatory Architectures Controlling Polymyxin B Resistance in Enteric Bacteria

  • Alexander Y. Mitrophanov equal contributor,

    equal contributor Contributed equally to this work with: Alexander Y. Mitrophanov, Mollie W. Jewett

    Affiliations: Howard Hughes Medical Institute, Washington University, St. Louis, Missouri, United States of America, Department of Molecular Microbiology, Washington University, St. Louis, Missouri, United States of America

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  • Mollie W. Jewett equal contributor,

    equal contributor Contributed equally to this work with: Alexander Y. Mitrophanov, Mollie W. Jewett

    Affiliation: Department of Molecular Microbiology, Washington University, St. Louis, Missouri, United States of America

    Current address: Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America

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  • Tricia J. Hadley,

    Affiliation: Department of Molecular Microbiology, Washington University, St. Louis, Missouri, United States of America

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  • Eduardo A. Groisman mail

    groisman@borcim.wustl.edu

    Affiliations: Howard Hughes Medical Institute, Washington University, St. Louis, Missouri, United States of America, Department of Molecular Microbiology, Washington University, St. Louis, Missouri, United States of America

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  • Published: October 24, 2008
  • DOI: 10.1371/journal.pgen.1000233

About the Authors

Alexander Y. Mitrophanov, Eduardo A. Groisman
Howard Hughes Medical Institute, Washington University, St. Louis, Missouri, United States of America
Alexander Y. Mitrophanov, Mollie W. Jewett, Tricia J. Hadley, Eduardo A. Groisman
Department of Molecular Microbiology, Washington University, St. Louis, Missouri, United States of America

Corresponding Author

Email: groisman@borcim.wustl.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AYM MWJ EAG. Performed the experiments: AYM MWJ TJH. Analyzed the data: AYM MWJ EAG. Wrote the paper: AYM MWJ EAG. Developed mathematical models: AYM.