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Research Article

Mechanisms Underlying Hypoxia Tolerance in Drosophila melanogaster: hairy as a Metabolic Switch

  • Dan Zhou mail,

    2zhou@ucsd.edu (DZ); ghaddad@ucsd.edu (GGH)

    Affiliations: Departments of Pediatrics (Section of Respiratory Medicine) and Neuroscience, University of California San Diego, La Jolla, California, United States of America, Rady Children's Hospital – San Diego, San Diego, California, United States of America

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  • Jin Xue,

    Affiliations: Departments of Pediatrics (Section of Respiratory Medicine) and Neuroscience, University of California San Diego, La Jolla, California, United States of America, Rady Children's Hospital – San Diego, San Diego, California, United States of America

    X
  • James C. K. Lai,

    Affiliation: College of Pharmacy, Idaho State University, Pocatello, Idaho, United States of America

    X
  • Nicholas J. Schork,

    Affiliation: Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, United States of America

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  • Kevin P. White,

    Affiliations: Institute for Genomics and Systems Biology, The University of Chicago, Chicago, Illinois, United States of America, Departments of Human Genetics and Ecology and Evolution, The University of Chicago, Chicago, Illinois, United States of America

    X
  • Gabriel G. Haddad mail

    2zhou@ucsd.edu (DZ); ghaddad@ucsd.edu (GGH)

    Affiliations: Departments of Pediatrics (Section of Respiratory Medicine) and Neuroscience, University of California San Diego, La Jolla, California, United States of America, Rady Children's Hospital – San Diego, San Diego, California, United States of America

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  • Published: October 17, 2008
  • DOI: 10.1371/journal.pgen.1000221

About the Authors

Dan Zhou, Jin Xue, Gabriel G. Haddad
Departments of Pediatrics (Section of Respiratory Medicine) and Neuroscience, University of California San Diego, La Jolla, California, United States of America
Dan Zhou, Jin Xue, Gabriel G. Haddad
Rady Children's Hospital – San Diego, San Diego, California, United States of America
James C. K. Lai
College of Pharmacy, Idaho State University, Pocatello, Idaho, United States of America
Nicholas J. Schork
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, United States of America
Kevin P. White
Institute for Genomics and Systems Biology, The University of Chicago, Chicago, Illinois, United States of America
Kevin P. White
Departments of Human Genetics and Ecology and Evolution, The University of Chicago, Chicago, Illinois, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DZ KPW GGH. Performed the experiments: DZ JCKL. Analyzed the data: DZ JX JCKL NJS. Contributed reagents/materials/analysis tools: NJS KPW. Wrote the paper: DZ JX GGH.