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Research Article

Mutability and Importance of a Hypermutable Cell Subpopulation that Produces Stress-Induced Mutants in Escherichia coli

  • Caleb Gonzalez,

    Affiliations: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Interdepartmental Graduate Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America

    X
  • Lilach Hadany equal contributor,

    equal contributor Contributed equally to this work with: Lilach Hadany, Rebecca G. Ponder

    Affiliation: Department of Biology, University of Iowa, Iowa City, Iowa, United States of America

    Current address: Department of Plant Science, Faculty of Life Science, Tel Aviv University, Tel Aviv, Israel

    X
  • Rebecca G. Ponder equal contributor,

    equal contributor Contributed equally to this work with: Lilach Hadany, Rebecca G. Ponder

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

    X
  • Mellanie Price,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

    Current address: Department of Thoracic/Head and Neck Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America

    X
  • P. J. Hastings,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

    X
  • Susan M. Rosenberg mail

    smr@bcm.edu

    Affiliations: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Interdepartmental Graduate Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America, Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America

    X
  • Published: October 03, 2008
  • DOI: 10.1371/journal.pgen.1000208

About the Authors

Caleb Gonzalez, Rebecca G. Ponder, Mellanie Price, P. J. Hastings, Susan M. Rosenberg
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
Caleb Gonzalez, Susan M. Rosenberg
Interdepartmental Graduate Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America
Lilach Hadany
Department of Biology, University of Iowa, Iowa City, Iowa, United States of America
Susan M. Rosenberg
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America
Susan M. Rosenberg
Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America
Susan M. Rosenberg
Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America

Corresponding Author

Email: smr@bcm.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CG RGP PJH SMR. Performed the experiments: CG RGP MP. Analyzed the data: CG LH RGP PJH SMR. Contributed reagents/materials/analysis tools: SMR. Wrote the paper: CG PJH SMR. Mathematical Modeling: LH.