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Research Article

A Myo6 Mutation Destroys Coordination between the Myosin Heads, Revealing New Functions of Myosin VI in the Stereocilia of Mammalian Inner Ear Hair Cells

  • Ronna Hertzano equal contributor,

    equal contributor Contributed equally to this work with: Ronna Hertzano, Ella Shalit, Agnieszka K. Rzadzinska

    Affiliation: Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Tel Aviv, Israel

    Current address: Department of Otorhinolaryngology Head and Neck Surgery, University of Maryland, Baltimore, Maryland, United States of America

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  • Ella Shalit equal contributor,

    equal contributor Contributed equally to this work with: Ronna Hertzano, Ella Shalit, Agnieszka K. Rzadzinska

    Affiliation: Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Tel Aviv, Israel

    X
  • Agnieszka K. Rzadzinska equal contributor,

    equal contributor Contributed equally to this work with: Ronna Hertzano, Ella Shalit, Agnieszka K. Rzadzinska

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

    X
  • Amiel A. Dror,

    Affiliation: Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Tel Aviv, Israel

    X
  • Lin Song,

    Affiliation: Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Uri Ron,

    Affiliation: Department of Biochemistry, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel

    X
  • Joshua T. Tan,

    Affiliation: Section of Cell and Developmental Biology, University of California San Diego, La Jolla, California, United States of America

    X
  • Alina Starovolsky Shitrit,

    Affiliation: Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Tel Aviv, Israel

    X
  • Helmut Fuchs,

    Affiliation: Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Experimental Genetics, Neuherberg, Germany

    X
  • Tama Hasson,

    Affiliation: Section of Cell and Developmental Biology, University of California San Diego, La Jolla, California, United States of America

    Current address: UCLA College of Letters and Science, Honors and Undergraduate Programs, University of California at Los Angeles, Los Angeles, California, United States of America

    X
  • Nir Ben-Tal,

    Affiliation: Department of Biochemistry, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel

    X
  • H. Lee Sweeney,

    Affiliation: Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Martin Hrabe de Angelis,

    Affiliations: Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Experimental Genetics, Neuherberg, Germany, Technical University of Munich, Munich, Germany

    X
  • Karen P. Steel,

    Affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

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  • Karen B. Avraham mail

    karena@post.tau.ac.il

    Affiliation: Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Tel Aviv, Israel

    X
  • Published: October 03, 2008
  • DOI: 10.1371/journal.pgen.1000207

About the Authors

Ronna Hertzano, Ella Shalit, Amiel A. Dror, Alina Starovolsky Shitrit, Karen B. Avraham
Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Tel Aviv, Israel
Agnieszka K. Rzadzinska, Karen P. Steel
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
Lin Song, H. Lee Sweeney
Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
Uri Ron, Nir Ben-Tal
Department of Biochemistry, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
Joshua T. Tan, Tama Hasson
Section of Cell and Developmental Biology, University of California San Diego, La Jolla, California, United States of America
Helmut Fuchs, Martin Hrabe de Angelis
Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Experimental Genetics, Neuherberg, Germany
Martin Hrabe de Angelis
Technical University of Munich, Munich, Germany

Corresponding Author

Email: karena@post.tau.ac.il

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RH ES AKR ASS TH NBT HLS KPS KBA. Performed the experiments: RH ES AKR AAD LS UR JTT ASS. Analyzed the data: RH ES AKR AAD LS UR TH NBT HLS KPS KBA. Contributed reagents/materials/analysis tools: RH HF MHdA. Wrote the paper: RH ES AKR ASS TH NBT HLS KPS KBA.