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Research Article

Heterokaryon-Based Reprogramming of Human B Lymphocytes for Pluripotency Requires Oct4 but Not Sox2

  • Carlos F. Pereira,

    Affiliation: Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom

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  • Rémi Terranova,

    Affiliation: Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom

    Current address: Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland

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  • Natalie K. Ryan,

    Affiliation: Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom

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  • Joana Santos,

    Affiliation: Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom

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  • Kelly J. Morris,

    Affiliation: Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom

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  • Wei Cui,

    Affiliation: Stem Cell Initiative, Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom

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  • Matthias Merkenschlager,

    Affiliation: Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom

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  • Amanda G. Fisher mail

    amanda.fisher@csc.mrc.ac.uk

    Affiliation: Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom

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  • Published: September 05, 2008
  • DOI: 10.1371/journal.pgen.1000170

About the Authors

Carlos F. Pereira, Rémi Terranova, Natalie K. Ryan, Joana Santos, Kelly J. Morris, Matthias Merkenschlager, Amanda G. Fisher
Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
Wei Cui
Stem Cell Initiative, Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom

Corresponding Author

Email: amanda.fisher@csc.mrc.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CFP RT MM AGF. Performed the experiments: CFP NKR JDARS KJM. Analyzed the data: CFP AGF. Contributed reagents/materials/analysis tools: WC. Wrote the paper: CFP MM AGF.