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Research Article

E2F and p53 Induce Apoptosis Independently during Drosophila Development but Intersect in the Context of DNA Damage

  • Nam-Sung Moon,

    Affiliations: Massachusetts General Hospital Cancer Research Center, Charlestown, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

    Current address: Department of Biology, McGill University, Montreal, Quebec, Canada

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  • Luisa Di Stefano,

    Affiliations: Massachusetts General Hospital Cancer Research Center, Charlestown, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Erick J. Morris,

    Affiliations: Massachusetts General Hospital Cancer Research Center, Charlestown, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Reena Patel,

    Affiliation: Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

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  • Kristin White,

    Affiliation: Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

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  • Nicholas J. Dyson mail

    Dyson@helix.mgh.harvard.edu

    Affiliations: Massachusetts General Hospital Cancer Research Center, Charlestown, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: August 08, 2008
  • DOI: 10.1371/journal.pgen.1000153

About the Authors

Nam-Sung Moon, Luisa Di Stefano, Erick J. Morris, Nicholas J. Dyson
Massachusetts General Hospital Cancer Research Center, Charlestown, Massachusetts, United States of America
Nam-Sung Moon, Luisa Di Stefano, Erick J. Morris, Nicholas J. Dyson
Harvard Medical School, Boston, Massachusetts, United States of America
Reena Patel, Kristin White
Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

Corresponding Author

Email: Dyson@helix.mgh.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NSM LDS EJM KW NJD. Performed the experiments: NSM LDS EJM RP. Analyzed the data: NSM LDS EJM KW NJD. Contributed reagents/materials/analysis tools: NSM LDS EJM RP KW. Wrote the paper: NSM LDS EJM KW NJD.