# wombat urls ß PLOS Genetics: The Identification of Zebrafish Mutants Showing Alterations in Senescence-Associated Biomarkers
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Research Article

The Identification of Zebrafish Mutants Showing Alterations in Senescence-Associated Biomarkers

  • Shuji Kishi equal contributor mail,

    equal contributor Contributed equally to this work with: Shuji Kishi, Peter E. Bayliss

    shuji.kishi@schepens.harvard.edu (SK); thomas_roberts@dfci.harvard.edu (TMR)

    Affiliations: Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Peter E. Bayliss equal contributor,

    equal contributor Contributed equally to this work with: Shuji Kishi, Peter E. Bayliss

    Affiliations: Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Junzo Uchiyama,

    Affiliations: Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Eriko Koshimizu,

    Affiliations: Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America, Tokyo University of Marine Science and Technology, Tokyo, Japan

    X
  • Jie Qi,

    Affiliations: Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America, College of Marine Life Science, Ocean University of China, Qingdao, China

    X
  • Purushothama Nanjappa,

    Affiliations: Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Shintaro Imamura,

    Affiliations: Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Asiful Islam,

    Affiliations: Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Donna Neuberg,

    Affiliations: Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

    X
  • Adam Amsterdam,

    Affiliation: Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

    X
  • Thomas M. Roberts mail

    shuji.kishi@schepens.harvard.edu (SK); thomas_roberts@dfci.harvard.edu (TMR)

    Affiliations: Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Published: August 15, 2008
  • DOI: 10.1371/journal.pgen.1000152

About the Authors

Shuji Kishi, Eriko Koshimizu, Jie Qi, Purushothama Nanjappa, Shintaro Imamura, Asiful Islam
Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, United States of America
Shuji Kishi, Eriko Koshimizu, Jie Qi, Purushothama Nanjappa, Shintaro Imamura, Asiful Islam
Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America
Peter E. Bayliss, Junzo Uchiyama, Thomas M. Roberts
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
Peter E. Bayliss, Junzo Uchiyama, Thomas M. Roberts
Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America
Eriko Koshimizu
Tokyo University of Marine Science and Technology, Tokyo, Japan
Jie Qi
College of Marine Life Science, Ocean University of China, Qingdao, China
Donna Neuberg
Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
Donna Neuberg
Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America
Adam Amsterdam
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Corresponding Authors

Competing Interests

In compliance with Harvard Medical School guidelines, we disclose the following consulting relationships: Novartis Pharmaceuticals, Inc. (T.M.R.) and Upstate Biotechnology (T.M.R.).

Author Contributions

Conceived and designed the experiments: SK PEB JU TR. Performed the experiments: SK PEB JU EK JQ PN SI AI. Analyzed the data: SK PEB JU EK JQ PN SI AI DN AA. Contributed reagents/materials/analysis tools: SK DN AA TR. Wrote the paper: SK PEB AA TR.