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Research Article

Off-Target Effects of Psychoactive Drugs Revealed by Genome-Wide Assays in Yeast

  • Elke Ericson,

    Affiliations: Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

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  • Marinella Gebbia,

    Affiliations: Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

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  • Lawrence E. Heisler,

    Affiliations: Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

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  • Jan Wildenhain,

    Affiliation: School of Biological Sciences, The University of Edinburgh, Edinburgh, United Kingdom

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  • Mike Tyers,

    Affiliations: Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada, School of Biological Sciences, The University of Edinburgh, Edinburgh, United Kingdom, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

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  • Guri Giaever,

    Affiliations: Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

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  • Corey Nislow mail

    corey.nislow@utoronto.ca

    Affiliations: Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada

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  • Published: August 08, 2008
  • DOI: 10.1371/journal.pgen.1000151

About the Authors

Elke Ericson, Marinella Gebbia, Lawrence E. Heisler, Guri Giaever
Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada
Elke Ericson, Marinella Gebbia, Lawrence E. Heisler, Mike Tyers, Guri Giaever, Corey Nislow
Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
Jan Wildenhain, Mike Tyers
School of Biological Sciences, The University of Edinburgh, Edinburgh, United Kingdom
Mike Tyers
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Corey Nislow
Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada

Corresponding Author

Email: corey.nislow@utoronto.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EE GG CN. Performed the experiments: EE MG. Analyzed the data: EE LEH JW. Contributed reagents/materials/analysis tools: LEH GG. Wrote the paper: EE MT GG CN.