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Research Article

Mitochondrial Targeting Adaptation of the Hominoid-Specific Glutamate Dehydrogenase Driven by Positive Darwinian Selection

  • Lia Rosso,

    Affiliation: Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland

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  • Ana C. Marques,

    Affiliation: Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland

    Current address: MRC Functional Genomics Unit (FGU), Department of Human Anatomy and Genetics, Oxford, United Kingdom

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  • Andreas S. Reichert,

    Affiliation: Cluster of Excellence “Macromolecular Complexes”, Mitochondriale Biologie, Fachbereich Medizin, Johann Wolfgang Goethe–Universität Frankfurt am Main, Frankfurt am Main, Germany

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  • Henrik Kaessmann mail

    henrik.kaessmann@unil.ch

    Affiliation: Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland

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  • Published: August 08, 2008
  • DOI: 10.1371/journal.pgen.1000150

About the Authors

Lia Rosso, Ana C. Marques, Henrik Kaessmann
Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
Andreas S. Reichert
Cluster of Excellence “Macromolecular Complexes”, Mitochondriale Biologie, Fachbereich Medizin, Johann Wolfgang Goethe–Universität Frankfurt am Main, Frankfurt am Main, Germany

Corresponding Author

Email: henrik.kaessmann@unil.ch

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LR ACM HK. Performed the experiments: LR ACM. Analyzed the data: LR ACM ASR HK. Contributed reagents/materials/analysis tools: ASR. Wrote the paper: LR ACM HK.